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Decreased risk of breast cancer associated with oral bisphosphonate therapy

Mathew, A and Brufsky, A (2012) Decreased risk of breast cancer associated with oral bisphosphonate therapy. Breast Cancer: Targets and Therapy, 4. 75 - 81.

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Abstract

Preclinical studies and adjuvant trials using bisphosphonates have found them to have an antitumor effect. Although major advances have been made in chemoprevention strategies with selective estrogen receptor modulators and aromatase inhibitors, their use has been fraught with significant adverse effects such as venous thromboembolic events and an increased risk for endometrial cancer. In this context, several recent observational studies have investigated a chemoprevention role for oral bisphosphonates in decreasing risk for breast cancer. This review will aim to summarize these studies and present a critical evaluation of the association between oral bisphosphonate use and breast cancer risk reduction. © 2012 Mathew and Brufsky, publisher and licensee Dove Medical Press Ltd.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Mathew, A
Brufsky, Aadb5@pitt.eduADB5
Date: 25 June 2012
Date Type: Publication
Journal or Publication Title: Breast Cancer: Targets and Therapy
Volume: 4
Page Range: 75 - 81
Schools and Programs: School of Medicine > Medicine
Refereed: Yes
Date Deposited: 03 Dec 2012 22:15
Last Modified: 29 Jan 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/16730

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