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UPDATE ON VACCINE DEVELOPMENT FOR RENAL CELL CANCER.

Chi, Nina and Maranchie, Jodi K and Appleman, Leonard J and Storkus, Walter J (2010) UPDATE ON VACCINE DEVELOPMENT FOR RENAL CELL CANCER. Open Access J Urol, 2010 (2). 125 - 141. ISSN 1179-1551

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Abstract

Renal cell carcinoma (RCC) remains a significant health concern that frequently presents as metastatic disease at the time of initial diagnosis. Current first-line therapeutics in the advanced stage setting include anti-angiogenic drugs that have yielded high rates of objective clinical response, however these tend to be transient in nature, with many patients becoming refractory to chronic treatment with these agents. Adjuvant immunotherapies remain viable candidates to sustain disease-free and overall patient survival. In particular, vaccines designed to optimize the activation, maintenance and recruitment of specific immunity within/into the tumor site continue to evolve. Based on the integration of increasingly refined immunomonitoring systems in both translational models and clinical trials, allowing for the improved understanding of treatment mechanism(s) of action, further refined (combinational) vaccine protocols are currently being developed and evaluated. This review will provide a brief history of RCC vaccine development, discussing the successes and deficiencies in such approaches, before providing a rationale for developing combinational vaccine approaches that may provide improved clinical benefits to patients with RCC.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Chi, Nina
Maranchie, Jodi Kjkm26@pitt.eduJKM26
Appleman, Leonard Jlja6@pitt.eduLJA6
Storkus, Walter J
Centers: Other Centers, Institutes, Offices, or Units > Hillman Cancer Center
Date: August 2010
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: Open Access J Urol
Volume: 2010
Number: 2
Page Range: 125 - 141
DOI or Unique Handle: 10.2147/rru.s7242
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Dermatology
School of Medicine > Immunology
School of Medicine > Medicine
School of Medicine > Urology
Refereed: Yes
Uncontrolled Keywords: Cellular Immunity, Combinational Therapy, Immunotherapy, Renal Cell Carcinoma, Vaccines
ISSN: 1179-1551
Funders: NCI NIH HHS (P01 CA109688), NCI NIH HHS (R01 CA114071)
Date Deposited: 12 Dec 2012 20:34
Last Modified: 14 Oct 2017 05:55
URI: http://d-scholarship.pitt.edu/id/eprint/16854

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