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Interleukin-6 inhibition for treatment of rheumatoid arthritis: A review of tocilizumab therapy

Patel, AM and Moreland, LW (2010) Interleukin-6 inhibition for treatment of rheumatoid arthritis: A review of tocilizumab therapy. Drug Design, Development and Therapy, 4. 263 - 278. ISSN 1177-8881

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Abstract

The dawn of the biologic era has been an exciting period for clinical research and patient care in rheumatoid arthritis (RA). Targeted biologic therapies have changed the outcome of this disease and made remission a realistic outcome for many patients. Tocilizumab (TCZ, Actemra®), is a humanized monoclonal antibody against the interleukin 6 receptor and has been approved in many countries for the treatment of moderate to severe RA. There have been a number of important clinical trials demonstrating the efficacy of TCZ in active rheumatoid arthritis. This review summarizes the data on efficacy, patient-reported outcomes, adverse events, and safety from some of these trials. Current trends in clinical practice will be discussed. It is difficult to place TCZ and many new medications in the algorithm of treatment at present. However, the next few years will hopefully reveal their role as we better define abnormal immune processes in individuals with RA.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Patel, AM
Moreland, LWlwm5@pitt.eduLWM5
Date: 1 December 2010
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: Drug Design, Development and Therapy
Volume: 4
Page Range: 263 - 278
DOI or Unique Handle: 10.2147/dddt.s14099
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Immunology
Refereed: Yes
ISSN: 1177-8881
Article Type: Review
Date Deposited: 12 Dec 2012 20:44
Last Modified: 02 Feb 2019 16:56
URI: http://d-scholarship.pitt.edu/id/eprint/16856

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