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Neurotrophic keratitis in a patient with disseminated lymphangiomatosis.

Knickelbein, Jared E and Stefko, Susan T and Charukamnoetkanok, Puwat (2009) Neurotrophic keratitis in a patient with disseminated lymphangiomatosis. Eye Brain, 1. 1 - 4. ISSN 1179-2744

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INTRODUCTION: Neurotrophic keratitis, a degenerative corneal disease caused by trigeminal nerve impairment, has many etiologies and remains very difficult to treat. METHODS: Case report of a 23-year-old male with a right corneal ulcer that failed to improve despite broad-spectrum antimicrobials. RESULTS: Prior diagnosis of disseminated lymphangiomatosis with a lesion in the right petrous apex effacing Meckel's (trigeminal) cave in conjunction with a history of nonhealing corneal abrasions suggested a neurotrophic etiology. Drawstring temporary tarsorrhaphy, in addition to antibiotics and autologous serum, lead to successful clearing of the infection and resolution of the corneal ulcer. Visual acuity improved from light perception (LP) at the peak of infection to 20/40 six weeks after treatment. CONCLUSIONS: To our knowledge, we report the first case of neurotrophic keratitis in a patient with disseminated lymphangiomatosis that caused a mass effect in Meckel's (trigeminal) cave leading to compression of the trigeminal nerve. The antibiotic-resistant corneal ulcer was successfully treated with drawstring tarsorrhaphy, confirming the utility of this therapeutic measure in treating neurotrophic keratitis.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Knickelbein, Jared E
Stefko, Susan T
Charukamnoetkanok, Puwat
Date: 2009
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: Eye Brain
Volume: 1
Page Range: 1 - 4
DOI or Unique Handle: 10.2147/eb.s6957
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Ophthalmology
Refereed: Yes
Uncontrolled Keywords: corneal abrasion, disseminated lymphangiomatosis, drawstring tarsorrhaphy, neurotrophic keratitis
ISSN: 1179-2744
Date Deposited: 12 Dec 2012 21:20
Last Modified: 30 Oct 2019 14:55


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