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Common variations in ALG9 are not associated with bipolar I disorder: A family-based study

Baysal, BE and Willet-Brozick, JE and Bacuna, SA and Detera-Wadleigh, S and Nimgaonkar, VL (2006) Common variations in ALG9 are not associated with bipolar I disorder: A family-based study. Behavioral and Brain Functions, 2. ISSN 1744-9081

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Abstract

Background: A mannosyltransferase gene (ALG9, DIBD I) at chromosome band 11q23 was previously identified to be disrupted by a balanced chromosomal translocation t(9; 11)(p24;q23) co-segregating with bipolar affective disorder in a small family. Inborn ALG9 deficiency (congenital disorders of glycosylation type IL) is associated with progressive microcephaly, seizures, developmental delay, and hepatomegaly. It is unknown whether common variations of ALG9 predispose to bipolar affective disorder. Methods: We tested five polymorphic markers spanning ALG9 (three intragenic and one upstream microsatellite repeats and one common missense variation, V2891 (rs10502151) for their association with bipolar I disorder in two pedigree series. The NIMH (National Institute of Mental Health) pedigrees had a total of 166 families showing transmissions to 250 affected offspring, whereas The PITT (The University of Pittsburgh) pedigrees had a total of 129 families showing transmissions to 135 cases. We used transmission disequilibrium test for the association analyses. Results: We identified three common and distinct haplotypes spanning the ALG9 gene. We found no statistically-significant evidence of transmission disequilibrium of marker alleles or multi-marker haplotypes to the affected offspring with bipolar I disorder. Conclusion: These results suggest that common variations in ALG9 do not play a major role in predisposition to bipolar affective disorder. © 2006 Baysal et al; licensee BioMed Central Ltd.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Baysal, BE
Willet-Brozick, JE
Bacuna, SA
Detera-Wadleigh, S
Nimgaonkar, VL
Date: 21 July 2006
Date Type: Publication
Journal or Publication Title: Behavioral and Brain Functions
Volume: 2
DOI or Unique Handle: 10.1186/1744-9081-2-25
Schools and Programs: Graduate School of Public Health > Human Genetics
School of Medicine > Obstetrics, Gynecology, and Reproductive Sciences
Refereed: Yes
ISSN: 1744-9081
Date Deposited: 15 Dec 2012 01:43
Last Modified: 02 Feb 2019 14:55
URI: http://d-scholarship.pitt.edu/id/eprint/16917

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