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Photonic crystal carbohydrate sensors: Low ionic strength sugar sensing

Asher, SA and Alexeev, VL and Goponenko, AV and Sharma, AC and Lednev, IK and Wilcox, CS and Finegold, DN (2003) Photonic crystal carbohydrate sensors: Low ionic strength sugar sensing. Journal of the American Chemical Society, 125 (11). 3322 - 3329. ISSN 0002-7863

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We developed a carbohydrate sensing material, which consists of a crystalline colloidal array (CCA) incorporated into a polyacrylamide hydrogel (PCCA) with pendent boronic acid groups. The embedded CCA diffracts visible light, and the PCCA diffraction wavelength reports on the hydrogel volume. This boronic acid PCCA responds to species containing vicinal cis diols such as carbohydrates. This PCCA photonic crystal sensing material responds to glucose in low ionic strength aqueous solutions by swelling and red shifting its diffraction as the glucose concentration increases. The hydrogel swelling results from a Donnan potential due to formation of boronate anion; the boronic acid pKa decreases upon glucose binding. This sensing material responds to glucose and other sugars at <50 μM concentrations in low ionic strength solutions.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Asher, SAasher@pitt.eduASHER
Alexeev, VL
Goponenko, AV
Sharma, AC
Lednev, IK
Wilcox, CSdaylite@pitt.eduDAYLITE
Finegold, DN
Date: 19 March 2003
Date Type: Publication
Journal or Publication Title: Journal of the American Chemical Society
Volume: 125
Number: 11
Page Range: 3322 - 3329
DOI or Unique Handle: 10.1021/ja021037h
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 0002-7863
MeSH Headings: Acrylic Resins--chemistry; Biosensing Techniques--methods; Boronic Acids--chemistry; Glucose--analysis; Hydrogels--chemistry; Osmolar Concentration
PubMed ID: 12630888
Date Deposited: 23 Jan 2013 21:46
Last Modified: 22 Jun 2021 11:55


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