Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

High ionic strength glucose-sensing photonic crystal

Alexeev, VL and Sharma, AC and Goponenko, AV and Das, S and Lednev, IK and Wilcox, CS and Finegold, DN and Asher, SA (2003) High ionic strength glucose-sensing photonic crystal. Analytical Chemistry, 75 (10). 2316 - 2323. ISSN 0003-2700

[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)


We demonstrate a colorimetric glucose recognition material consisting of a crystalline colloidal array embedded within a polyacrylamide-poly(ethylene glycol) (PEG) hydrogel, or a polyacrylamide - 15-crown-5 hydrogel, with pendent phenylboronic acid groups. We utilize a new molecular recognition motif, in which boronic acid and PEG (or crown ether) functional groups are prepositioned in a photonic crystal hydrogel, such that glucose self-assembles these functional groups into a supramolecular complex. The formation of the complex results in an increase in the hydrogel cross-linking, which for physiologically relevant glucose concentration blue shifts the photonic crystal diffraction. The visually evident diffraction color shifts across the visible spectral region over physiologically important glucose concentration ranges. These materials respond to glucose at physiological ionic strengths and pH values and are selective in their mode of response for glucose over galactose, mannose, and fructose. Thus, we have developed a new recognition motif for glucose that shows promise for the fabrication of noninvasive or minimally invasive in vivo glucose sensing for patients with diabetes mellitus.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Alexeev, VL
Sharma, AC
Goponenko, AV
Das, S
Lednev, IK
Wilcox, CSdaylite@pitt.eduDAYLITE
Finegold, DN
Asher, SAasher@pitt.eduASHER
Date: 15 May 2003
Date Type: Publication
Journal or Publication Title: Analytical Chemistry
Volume: 75
Number: 10
Page Range: 2316 - 2323
DOI or Unique Handle: 10.1021/ac030021m
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 0003-2700
MeSH Headings: Biosensing Techniques--methods; Blood Glucose--analysis; Boronic Acids--chemistry; Colloids--chemistry; Colorimetry--methods; Crystallization; Ethers, Cyclic--chemistry; Humans; Hydrogels--chemistry; Osmolar Concentration; Polymers--chemistry
PubMed ID: 12918972
Date Deposited: 23 Jan 2013 21:46
Last Modified: 02 Feb 2019 14:56


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item