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Tear glucose analysis for the noninvasive detection and monitoring of diabetes mellitus

Baca, JT and Finegold, DN and Asher, SA (2007) Tear glucose analysis for the noninvasive detection and monitoring of diabetes mellitus. Ocular Surface, 5 (4). 280 - 293. ISSN 1542-0124

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One approach to the noninvasive monitoring of blood glucose concentration is to monitor glucose concentrations in tear fluid. While several methods for sensing glucose in tear fluid have been proposed, controversy remains as to the precise concentrations of tear glucose in normal and diabetic subjects and as to whether tear fluid glucose concentrations correlate with blood glucose concentrations. This review covers the present undetstanding of the physiology of glucose transport in tears, the regulation of the aqueous tear fraction, and studies of tear glucose concentration over the last 80 years. The various tear collection methods employed greatly influence the measured tear glucose concentrations. Studies that involve mechanical irritation of the conjunctiva during sampling measure the highest tear glucose concentrations, while studies that avoid tear stimulation measure the lowest concentrations. Attempts to monitor tear glucose concentration in situ by using contact lens-based sensing devices are discussed, and new observations are presented oftear glucose concentration obtained by a method designed to avoid tear stimulation. These studies indicate the importance oif the sampling method in determining tear glucose concentrations. On the basis of these results, we discuss the future of in vivo tear glucose sensing and outline the studies needed to resolve the remaining questions about the relationship between tear and blood glucose concentrations. © 2007 Ethis Communications, Inc.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Baca, JT
Finegold, DN
Asher, SAasher@pitt.eduASHER
Date: 1 January 2007
Date Type: Publication
Journal or Publication Title: Ocular Surface
Volume: 5
Number: 4
Page Range: 280 - 293
DOI or Unique Handle: 10.1016/s1542-0124(12)70094-0
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 1542-0124
MeSH Headings: Animals; Aqueous Humor--metabolism; Diabetes Mellitus--diagnosis; Glucose--analysis; Glucose--metabolism; Humans; Monitoring, Physiologic--methods; Tears--chemistry; Tears--metabolism
PubMed ID: 17938838
Date Deposited: 21 Feb 2013 22:34
Last Modified: 02 Feb 2019 14:56


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