Zhang, F and Zhang, W and Zhang, Y and Curran, DP and Liu, G
(2009)
Synthesis and applications of a light-fluorous glycosyl donor.
Journal of Organic Chemistry, 74 (6).
2594 - 2597.
ISSN 0022-3263
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Abstract
A new method using a light-fluorous glycosyl donor and an orthogonal tagging strategy to synthesize oligosaccharides and glycoconjugates has been developed. The glycosyl donor orthogonally protected with a C 8F 17-Silyl tag and benzoyl groups was reacted with excess amounts of glycosyl acceptor. Fluorous solid-phase extraction separated the glycosylated product and unreacted glycosyl acceptor. This new protocol has high reaction efficiency and easy separation, which was demonstrated in the synthesis of an unprotected trisaccharide and an O-glycosylated serine in this paper. © 2009 American Chemical Society.
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Details
Item Type: |
Article
|
Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
---|
Zhang, F | | | | Zhang, W | | | | Zhang, Y | | | | Curran, DP | curran@pitt.edu | CURRAN | | Liu, G | | | |
|
Date: |
20 March 2009 |
Date Type: |
Publication |
Journal or Publication Title: |
Journal of Organic Chemistry |
Volume: |
74 |
Number: |
6 |
Page Range: |
2594 - 2597 |
DOI or Unique Handle: |
10.1021/jo9000993 |
Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
Refereed: |
Yes |
ISSN: |
0022-3263 |
MeSH Headings: |
Glycoconjugates--chemical synthesis; Glycosylation; Methods; Oligosaccharides--chemical synthesis; Solid Phase Extraction |
Other ID: |
NLM NIHMS140858, NLM PMC2754202 |
PubMed Central ID: |
PMC2754202 |
PubMed ID: |
19216499 |
Date Deposited: |
27 Feb 2013 15:53 |
Last Modified: |
11 Jun 2021 22:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/17501 |
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