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A putative ABC-transport operon of Mycobacterium smegmatis

Barsom, EK and Hatfull, GF (1997) A putative ABC-transport operon of Mycobacterium smegmatis. Gene, 185 (1). 127 - 132. ISSN 0378-1119

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Abstract

We have recently described the mpr gene of Mycobacterium smegmatis whose product confers resistance to mycobacteriophages L5 and D29 when overproduced. We have determined the nt sequence of approximately 3.5 kb immediately adjacent to mpr which appears to encode components of an ATP-binding cassette (ABC) transport system. Four closely-spaced open reading frames (ORF) were identified although two of these may cooperate to produce an integral membrane component of the transport system via a programmed translational frameshift. Another putative protein is also predicted to be an integral membrane protein, while the third is an ABC-transporter protein. We propose that these three putative proteins form a mycobacterial membrane-bound complex involved in protein-dependent transport. This is the first ABC-transport system to be described in mycobacteria.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Barsom, EK
Hatfull, GFgfh@pitt.eduGFH
Date: 20 February 1997
Date Type: Publication
Journal or Publication Title: Gene
Volume: 185
Number: 1
Page Range: 127 - 132
DOI or Unique Handle: 10.1016/s0378-1119(96)00650-6
Schools and Programs: Dietrich School of Arts and Sciences > Biological Sciences
Refereed: Yes
ISSN: 0378-1119
MeSH Headings: ATP-Binding Cassette Transporters--genetics; Amino Acid Sequence; Bacterial Outer Membrane Proteins--genetics; Base Sequence; Cell Wall--genetics; Chromosome Mapping; Cloning, Molecular; Frameshifting, Ribosomal--genetics; Membrane Transport Proteins--genetics; Molecular Sequence Data; Mycobacterium--genetics; Open Reading Frames; Operon; Sequence Alignment; Sequence Homology, Amino Acid
PubMed ID: 9034323
Date Deposited: 01 Mar 2013 15:35
Last Modified: 02 Feb 2019 15:57
URI: http://d-scholarship.pitt.edu/id/eprint/17557

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