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Evolutionary relationships among diverse bacteriophages and prophages: All the world's a phage

Hendrix, RW and Smith, MCM and Burns, RN and Ford, ME and Hatfull, GF (1999) Evolutionary relationships among diverse bacteriophages and prophages: All the world's a phage. Proceedings of the National Academy of Sciences of the United States of America, 96 (5). 2192 - 2197. ISSN 0027-8424

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Abstract

We report DNA and predicted protein sequence similarities, implying homology, among genes of double-stranded DNA (dsDNA) bacteriophages and prophages spanning a broad phylogenetic range of host bacteria. The sequence matches reported here establish genetic connections, not always direct, among the lambdoid phages of Escherichia coli, phage φC31 of Streptomyces, phages of Mycobacterium, a previously unrecognized cryptic prophage, Φflu, in the Haemophilus influenzae genome, and two small prophage-like elements, ΦbRv1 and ΦbRv2, in the genome of Mycobacterium tuberculosis. The results imply that these phage genes, and very possibly all of the dsDNA tailed phages, share common ancestry. We propose a model for the genetic structure and dynamics of the global phage population in which all dsDNA phage genomes are mosaics with access, by horizontal exchange, to a large common genetic pool but in which access to the gene pool is not uniform for all phage.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Hendrix, RWrhx@pitt.eduRHX
Smith, MCM
Burns, RN
Ford, ME
Hatfull, GFgfh@pitt.eduGFH
Date: 2 March 1999
Date Type: Publication
Journal or Publication Title: Proceedings of the National Academy of Sciences of the United States of America
Volume: 96
Number: 5
Page Range: 2192 - 2197
DOI or Unique Handle: 10.1073/pnas.96.5.2192
Schools and Programs: Dietrich School of Arts and Sciences > Biological Sciences
Refereed: Yes
ISSN: 0027-8424
MeSH Headings: Bacteriophages--classification; Bacteriophages--genetics; Bacteriophages--physiology; Biological Evolution; Coliphages--classification; Coliphages--genetics; DNA, Viral--genetics; Escherichia coli--genetics; Escherichia coli--virology; Evolution, Molecular; Genome, Bacterial; Genome, Viral; Haemophilus influenzae--genetics; Haemophilus influenzae--virology; Molecular Sequence Data; Mycobacterium--genetics; Mycobacterium--virology; Mycobacterium tuberculosis--genetics; Mycobacterium tuberculosis--virology; Phylogeny; Salmonella Phages--classification; Salmonella Phages--genetics; Streptomyces--genetics; Streptomyces--virology
Other ID: NLM PMC26759
PubMed Central ID: PMC26759
PubMed ID: 10051617
Date Deposited: 01 Mar 2013 15:28
Last Modified: 02 Feb 2019 15:57
URI: http://d-scholarship.pitt.edu/id/eprint/17579

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