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Genome structure of mycobacteriophage D29: Implications for phage evolution

Ford, ME and Sarkis, GJ and Belanger, AE and Hendrix, RW and Hatfull, GF (1998) Genome structure of mycobacteriophage D29: Implications for phage evolution. Journal of Molecular Biology, 279 (1). 143 - 164. ISSN 0022-2836

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Abstract

Mycobacteriophage D29 is a lytic phage that infects both fast and slow-growing mycobacterial species. The complete genome sequence of D29 reveals that it is a close relative of the temperate mycobacteriophage L5, whose sequence has been described previously. The overall organization of the D29 genome is similar to that of L5, although a 3.6 kb deletion removing the repressor gene accounts for the inability of D29 to form lysogens. Comparison of the two genomes shows that they are punctuated by a large number of insertions, deletions, and substitutions of genes, consistent with the genetic mosaicism of lambdoid phages.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Ford, ME
Sarkis, GJ
Belanger, AE
Hendrix, RWrhx@pitt.eduRHX
Hatfull, GFgfh@pitt.eduGFH
Date: 29 May 1998
Date Type: Publication
Journal or Publication Title: Journal of Molecular Biology
Volume: 279
Number: 1
Page Range: 143 - 164
DOI or Unique Handle: 10.1006/jmbi.1997.1610
Schools and Programs: Dietrich School of Arts and Sciences > Biological Sciences
Refereed: Yes
ISSN: 0022-2836
MeSH Headings: Amino Acid Sequence; Base Sequence; DNA, Viral--chemistry; Evolution, Molecular; Genes, Viral--genetics; Genes, Viral--physiology; Human Genome Project; Lysogeny; Molecular Sequence Data; Mycobacteriophages--genetics; Mycobacteriophages--ultrastructure; Mycobacterium--virology; Nucleic Acid Conformation; Phenotype; RNA, Transfer--chemistry; RNA, Transfer--genetics; RNA, Viral--chemistry; RNA, Viral--genetics; Sequence Alignment
PubMed ID: 9636706
Date Deposited: 01 Mar 2013 19:10
Last Modified: 19 Jan 2019 14:55
URI: http://d-scholarship.pitt.edu/id/eprint/17600

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