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Transcriptional regulation of repressor synthesis in mycobacteriophage L5

Nesbit, CE and Levin, ME and Donnelly Wu, MK and Hatfull, GF (1995) Transcriptional regulation of repressor synthesis in mycobacteriophage L5. Molecular Microbiology, 17 (6). 1045 - 1056. ISSN 0950-382X

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Abstract

Mycobacteriophage L5 is a temperate phage of the mycobacteria that forms stable lysogens in Mycobacterium smegmatis. Lysogeny is maintained by the putative repressor, the gene 71 product, which also mediates immunity to superinfection. We show here that there are three promoters located upstream of gene 71 which are active in an L5 lysogen but which do not require any phage‐encoded proteins. In early lytic growth, gene 71 is also transcribed from a promoter, Pleft, located at the right end of the genome and which appears to be a target of gp71 regulation. A model is given for the regulation of L5 life cycles. Copyright © 1995, Wiley Blackwell. All rights reserved


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Nesbit, CE
Levin, ME
Donnelly Wu, MK
Hatfull, GFgfh@pitt.eduGFH
Date: 1 January 1995
Date Type: Publication
Journal or Publication Title: Molecular Microbiology
Volume: 17
Number: 6
Page Range: 1045 - 1056
DOI or Unique Handle: 10.1111/j.1365-2958.1995.mmi_17061045.x
Schools and Programs: Dietrich School of Arts and Sciences > Biological Sciences
Refereed: Yes
ISSN: 0950-382X
MeSH Headings: Amino Acid Sequence; Bacteriolysis; Base Sequence; DNA-Binding Proteins--biosynthesis; DNA-Binding Proteins--genetics; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Viral; Lysogeny; Molecular Sequence Data; Mutagenesis; Mycobacteriophages--genetics; Mycobacteriophages--physiology; Mycobacterium--metabolism; Mycobacterium--virology; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Messenger--biosynthesis; RNA, Viral--biosynthesis; Recombinant Fusion Proteins--biosynthesis; Repressor Proteins--biosynthesis; Repressor Proteins--genetics; Transcription, Genetic; Viral Proteins--biosynthesis; Viral Proteins--genetics
PubMed ID: 8594325
Date Deposited: 12 Mar 2013 19:03
Last Modified: 02 Feb 2019 15:57
URI: http://d-scholarship.pitt.edu/id/eprint/17639

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