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New use of BCG for recombinant vaccines

Stover, CK and De La Cruz, VF and Fuerst, TR and Burlein, JE and Benson, LA and Bennett, LT and Bansal, GP and Young, JF and Lee, MH and Hatfull, GF and Snapper, SB and Barletta, RG and Jacobs, WR and Bloom, BR (1991) New use of BCG for recombinant vaccines. Nature, 351 (6326). 456 - 460. ISSN 0028-0836

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BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed to allow expression of foreign antigens in BCG. These recombinant BCG strains can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice. © 1991 Nature Publishing Group.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Stover, CK
De La Cruz, VF
Fuerst, TR
Burlein, JE
Benson, LA
Bennett, LT
Bansal, GP
Young, JF
Lee, MH
Hatfull, GFgfh@pitt.eduGFH
Snapper, SB
Barletta, RG
Jacobs, WR
Bloom, BR
Date: 1 January 1991
Date Type: Publication
Journal or Publication Title: Nature
Volume: 351
Number: 6326
Page Range: 456 - 460
DOI or Unique Handle: 10.1038/351456a0
Schools and Programs: Dietrich School of Arts and Sciences > Biological Sciences
Refereed: Yes
ISSN: 0028-0836
MeSH Headings: Animals; Antigens--genetics; Antigens--immunology; Antigens, Bacterial--genetics; Antigens, Bacterial--immunology; Antigens, Viral--genetics; Antigens, Viral--immunology; BCG Vaccine--genetics; BCG Vaccine--immunology; Base Sequence; Cloning, Molecular; Escherichia coli--genetics; Gene Expression; Genes, Bacterial; Genetic Vectors; HIV Antigens--genetics; HIV-1--immunology; Heat-Shock Proteins--genetics; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mycobacterium bovis--genetics; Regulatory Sequences, Nucleic Acid; Vaccines, Synthetic--genetics; Vaccines, Synthetic--immunology; beta-Galactosidase--genetics
PubMed ID: 1904554
Date Deposited: 12 Mar 2013 19:34
Last Modified: 02 Feb 2019 15:57


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