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Second-generation tags for fluorous chemistry exemplified with a new fluorous Mitsunobu reagent

Chu, Q and Henry, C and Curran, DP (2008) Second-generation tags for fluorous chemistry exemplified with a new fluorous Mitsunobu reagent. Organic Letters, 10 (12). 2453 - 2456. ISSN 1523-7060

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(Chemical Equation Presented) A new fluorous DEAD reagent bearing two perfluoro-tert-butyloxy groups with propylene spacers shows excellent promise for use in fluorous Mitsunobu reactions. Pure target products were obtained in good yields after removing fluorous byproducts by FSPE. The new reagent serves as a prototype for a greener second generation of fluorous reagents bearing tags that are not expected to degrade in the environment to compounds that are highly persistent or that bioaccumulate in higher organisms. © 2008 American Chemical Society.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Chu, Q
Henry, C
Curran, DPcurran@pitt.eduCURRAN
Date: 1 December 2008
Date Type: Publication
Journal or Publication Title: Organic Letters
Volume: 10
Number: 12
Page Range: 2453 - 2456
DOI or Unique Handle: 10.1021/ol800750q
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 1523-7060
MeSH Headings: Alkenes--chemistry; Azo Compounds--chemistry; Hydrocarbons, Fluorinated--chemical synthesis; Hydrocarbons, Fluorinated--chemistry; Indicators and Reagents; Models, Molecular; Molecular Structure
PubMed ID: 18484733
Date Deposited: 12 Mar 2013 19:35
Last Modified: 02 Feb 2019 15:59


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