Kim, SO and Sakchaisri, K and Thimmegowda, NR and Soung, NK and Jang, JH and Kim, YS and Lee, KS and Kwon, YT and Asami, Y and Ahn, JS and Erikson, RL and Kim, BY
(2013)
STK295900, a Dual Inhibitor of Topoisomerase 1 and 2, Induces G<inf>2</inf> Arrest in the Absence of DNA Damage.
PLoS ONE, 8 (1).
Abstract
STK295900, a small synthetic molecule belonging to a class of symmetric bibenzimidazoles, exhibits antiproliferative activity against various human cancer cell lines from different origins. Examining the effect of STK295900 in HeLa cells indicates that it induces G2 phase arrest without invoking DNA damage. Further analysis shows that STK295900 inhibits DNA relaxation that is mediated by topoisomerase 1 (Top 1) and topoisomerase 2 (Top 2) in vitro. In addition, STK295900 also exhibits protective effect against DNA damage induced by camptothecin. However, STK295900 does not affect etoposide-induced DNA damage. Moreover, STK295900 preferentially exerts cytotoxic effect on cancer cell lines while camptothecin, etoposide, and Hoechst 33342 affected both cancer and normal cells. Therefore, STK295900 has a potential to be developed as an anticancer chemotherapeutic agent. © 2013 Kim et al.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
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Kim, SO | | | | Sakchaisri, K | | | | Thimmegowda, NR | | | | Soung, NK | | | | Jang, JH | | | | Kim, YS | | | | Lee, KS | | | | Kwon, YT | yok5@pitt.edu | YOK5 | | Asami, Y | | | | Ahn, JS | | | | Erikson, RL | | | | Kim, BY | | | |
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Date: |
29 January 2013 |
Date Type: |
Publication |
Journal or Publication Title: |
PLoS ONE |
Volume: |
8 |
Number: |
1 |
DOI or Unique Handle: |
10.1371/journal.pone.0053908 |
Schools and Programs: |
School of Pharmacy > Pharmaceutical Sciences |
Refereed: |
Yes |
Other ID: |
NLM PMC3551932 |
PubMed Central ID: |
PMC3551932 |
PubMed ID: |
23349762 |
Date Deposited: |
14 Mar 2013 14:37 |
Last Modified: |
22 Jun 2021 15:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/17732 |
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