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Synthetic approaches to homocamptothecin antitumor agents

Curran, DP (2008) Synthetic approaches to homocamptothecin antitumor agents. Comptes Rendus Chimie, 11 (11-12). 1574 - 1583. ISSN 1631-0748

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Homocamptothecins are proving to be an especially interesting class of anti-cancer agents because they resemble standard camptothecins in cytotoxicity but have very different pharmacodyanamic properties. This review summarizes synthetic approaches to the parent homocamptothecin and its analogs. Three powerful and general routes-the Lavergne-Comins route, the cascade radical annulation route, and the Friedlander route-have been put into place to make homocamptothecins. These routes are compared and contrasted. Together, they have driven the SAR, preclinical, and clinical development of this class of anti-cancer agents. © 2008 Académie des sciences.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Curran, DPcurran@pitt.eduCURRAN
Date: 1 November 2008
Date Type: Publication
Journal or Publication Title: Comptes Rendus Chimie
Volume: 11
Number: 11-12
Page Range: 1574 - 1583
DOI or Unique Handle: 10.1016/j.crci.2008.10.002
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 1631-0748
Date Deposited: 20 Mar 2013 16:46
Last Modified: 02 Feb 2019 15:58


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