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Representativeness of women enrolled in a clinical gynecologic cancer research database at UPMC Magee-Womens Hospital, 2008-2011

Toney, Nicole (2013) Representativeness of women enrolled in a clinical gynecologic cancer research database at UPMC Magee-Womens Hospital, 2008-2011. Master Essay, University of Pittsburgh.

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Abstract

Introduction- Gynecologic cancers contribute to a significant degree of morbidity and mortality in the female population within the United States. These cancers, classified as endometrial, ovarian, cervical, vaginal and vulvar have distinct risk factors, prevention strategies, symptomatologies, and treatment courses. As a result, the diverse nature of gynecologic cancer presents unique challenges to public health. The Division of Gynecologic Oncology at Magee Womens Hospital (MWH) has developed the Gynecologic Oncology Research Database (GORDy), a biorepository, which stores patient information and biospecimens (malignant and benign) for research from patients undergoing gynecologic surgery. To date, no studies have compared the characteristics of women within the database to those women within the total gynecologic cancer population at MWH. Methods- This study reviews participants and non-participants diagnosed with a gynecologic cancer between January 1, 2008 and December 31, 2011. Demographic information, reproductive history, and disease factors were assessed between the patients using the two sample t-test, chi-square test of independence or the Fisher’s Exact test as appropriate. Cox proportional-hazards regression and logistic regression analyses were performed. Results- In the study period, 2,144 women were diagnosed with a primary gynecologic cancer. 468 women participated in the biorepository (269 endometrial, 154 ovarian, and 45 cervical, vulvar, vaginal cancer patients). Participation increased annually, while incidence remained stable in the population. Participants tended to be older (p=0.0029), postmenopausal (p=0.0445) and white (p=0.0034) compared to non-participants. Endometrial participants tended to have a higher body mass index (p=0.0931) and were more likely to be white (p=0.0010). Ovarian cancer participants tended to be older (p=0.0471). No significant differences were seen in the cervical, vulvar, vaginal cancer group. Kaplan-Meier analysis showed no differences in disease progression and survival among all groups. Conclusions- Though participants tended to be older, postmenopausal and white they were similar to the non-participants in a number of social and clinical characteristics that normally confound studies. This analysis demonstrates that researchers should assess the criteria used for patient recruitment, particularly age, BMI and race. Increasing patient participation in the biorepository and data bank will increase representativeness and provide researchers with a robust collection of samples for future research projects.


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Details

Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Toney, Nicole
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
Committee ChairVoorhees, Ronald E.rev12@pitt.eduREV12UNSPECIFIED
Committee MemberBunker, ClareannBUNKERC@pitt.eduBUNKERCUNSPECIFIED
Committee MemberLinkov, Faina Yfyl1@pitt.eduFYL1UNSPECIFIED
Committee MemberModugno, Francesmaryfm@cs.cmu.eduOVARIANUNSPECIFIED
Date: 8 April 2013
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Publisher: University of Pittsburgh
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Epidemiology
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Date Deposited: 06 May 2015 21:46
Last Modified: 01 Jul 2019 14:01
URI: http://d-scholarship.pitt.edu/id/eprint/18410

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