The azido acid approach to β-peptides: parallel synthesis of a tri-β-peptide library by fluorous tagging

Wang, X and Nelson, SG and Curran, DP (2007) The azido acid approach to β-peptides: parallel synthesis of a tri-β-peptide library by fluorous tagging. Tetrahedron, 63 (27). 6141 - 6145. ISSN 0040-4020

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Abstract

A small tri-β-peptide library was prepared starting from three enantio- and diastereopure azido acids. Fluorous tagging followed by two cycles of azide reduction, fluorous solid phase extraction (f-SPE), peptide coupling with the original azido acids, and f-SPE provided 27 protected azido peptides. Reduction and HPLC purification provided 25 of the 27 targeted tri-β-peptides in acceptable yields and excellent purities. © 2007 Elsevier Ltd. All rights reserved.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Wang, X Nelson, SG Curran, DP curran@pitt.edu CURRAN
Date:	2 July 2007
Date Type:	Publication
Journal or Publication Title:	Tetrahedron
Volume:	63
Number:	27
Page Range:	6141 - 6145
DOI or Unique Handle:	10.1016/j.tet.2007.03.034
Schools and Programs:	Dietrich School of Arts and Sciences > Chemistry
Refereed:	Yes
ISSN:	0040-4020
PubMed Central ID:	PMC2701693
PubMed ID:	19562094
Date Deposited:	30 Apr 2013 21:32
Last Modified:	05 Feb 2019 16:55
URI:	http://d-scholarship.pitt.edu/id/eprint/18566

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