Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Haplotype analysis of the folate-related genes MTHFR, MTRR, and MTR and migraine with aura

Roecklein, KA and Scher, AI and Smith, A and Harris, T and Eiriksdottir, G and Garcia, M and Gudnason, V and Launer, LJ (2013) Haplotype analysis of the folate-related genes MTHFR, MTRR, and MTR and migraine with aura. Cephalalgia, 33 (7). 469 - 482. ISSN 0333-1024

[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)


Aims: The C677T variant in the methylenetetrahydrofolate reductase (MTHFR; EC enzyme, a key player in the folate metabolic pathway, has been associated with increased risk of migraine with aura. Other genes encoding molecular components of this pathway include methionine synthase (MTR; EC and methionine synthase reductase (MTRR; EC among others. We performed a haplotype analysis of migraine risk and MTHFR, MTR, and MTRR. Methods: Study participants are from a random sub-sample participating in the population-based AGES-Reykjavik Study, including subjects with non-migraine headache (n=367), migraine without aura (n=85), migraine with aura (n=167), and no headache (n=1347). Haplotypes spanning each gene were constructed using Haploview. Association testing was performed on single SNP and haplotypes using logistic regression, controlling for demographic and cardiovascular risk factors and correcting for multiple testing. Results: Haplotype analysis suggested an association between MTRR haplotypes and reduced risk of migraine with aura. All other associations were not significant after correcting for multiple testing. Conclusions: These results suggest that MTRR variants may protect against migraine with aura in an older population. © 2013 International Headache Society.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Roecklein, KAkroeck@pitt.eduKROECK
Scher, AI
Smith, A
Harris, T
Eiriksdottir, G
Garcia, M
Gudnason, V
Launer, LJ
Date: 1 May 2013
Date Type: Publication
Journal or Publication Title: Cephalalgia
Volume: 33
Number: 7
Page Range: 469 - 482
DOI or Unique Handle: 10.1177/0333102413477738
Schools and Programs: Dietrich School of Arts and Sciences > Psychology
Refereed: Yes
ISSN: 0333-1024
Date Deposited: 03 May 2013 21:43
Last Modified: 26 Jun 2018 10:55


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item