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The aging hippocampus: Interactions between exercise, depression, and BDNF

Erickson, KI and Miller, DL and Roecklein, KA (2012) The aging hippocampus: Interactions between exercise, depression, and BDNF. Neuroscientist, 18 (1). 82 - 97. ISSN 1073-8584

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Late adulthood is associated with increased hippocampal atrophy and dysfunction. Although there are multiple paths by which hippocampal deterioration occurs in late life, the authors discuss the evidence that a single nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene and age-related changes in BDNF protein or receptor expression contribute to hippocampal atrophy. The authors conclude that few studies have tested whether BDNF mediates age-related hippocampal atrophy and memory impairment. However, there is strong evidence that decreased BDNF is associated with age-related hippocampal dysfunction, memory impairment, and increased risk for depression, whereas increasing BDNF by aerobic exercise appears to ameliorate hippocampal atrophy, improve memory function, and reduce depression. Importantly, the most consistent associations between BDNF and hippocampal dysfunction have emerged from research on BDNF protein expression in rodents and serum and plasma concentrations of BDNF in humans. Current research suggests that the BDNF val66met polymorphism may be only weakly associated with hippocampal atrophy in late adulthood. These conclusions are interpreted in relation to age-related memory impairment and preventions for hippocampal atrophy. © SAGE Publications 2012.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Erickson, KIkiericks@pitt.eduKIERICKS
Miller, DL
Roecklein, KAkroeck@pitt.eduKROECK
Date: 1 February 2012
Date Type: Publication
Journal or Publication Title: Neuroscientist
Volume: 18
Number: 1
Page Range: 82 - 97
DOI or Unique Handle: 10.1177/1073858410397054
Schools and Programs: Dietrich School of Arts and Sciences > Psychology
Refereed: Yes
ISSN: 1073-8584
Article Type: Review
Date Deposited: 03 May 2013 15:45
Last Modified: 02 Feb 2019 16:57


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