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A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder

Roecklein, KA and Rohan, KJ and Duncan, WC and Rollag, MD and Rosenthal, NE and Lipsky, RH and Provencio, I (2009) A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder. Journal of Affective Disorders, 114 (1-3). 279 - 285. ISSN 0165-0327

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Background: Melanopsin, a non-visual photopigment, may play a role in aberrant responses to low winter light levels in Seasonal Affective Disorder (SAD). We hypothesize that functional sequence variation in the melanopsin gene could contribute to increasing the light needed for normal functioning during winter in SAD. Methods: Associations between alleles, genotypes, and haplotypes of melanopsin in SAD participants (n = 130) were performed relative to controls with no history of psychopathology (n = 90). Results: SAD participants had a higher frequency of the homozygous minor genotype (T/T) for the missense variant rs2675703 (P10L) than controls, compared to the combined frequencies of C/C and C/T. Individuals with the T/T genotype were 5.6 times more likely to be in the SAD group than the control group, and all 7 (5%) of individuals with the T/T genotype at P10L were in the SAD group. Limitations: The study examined only one molecular component of the non-visual light input pathway, and recruitment methods for the comparison groups differed. Conclusion: These findings support the hypothesis that melanopsin variants may predispose some individuals to SAD. Characterizing the genetic basis for deficits in the non-visual light input pathway has the potential to define mechanisms underlying the pathological response to light in SAD, which may improve treatment. © 2008 Elsevier B.V.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Roecklein, KAkroeck@pitt.eduKROECK
Rohan, KJ
Duncan, WC
Rollag, MD
Rosenthal, NE
Lipsky, RH
Provencio, I
Date: 1 April 2009
Date Type: Publication
Journal or Publication Title: Journal of Affective Disorders
Volume: 114
Number: 1-3
Page Range: 279 - 285
DOI or Unique Handle: 10.1016/j.jad.2008.08.005
Schools and Programs: Dietrich School of Arts and Sciences > Psychology
Refereed: Yes
ISSN: 0165-0327
PubMed ID: 18804284
Date Deposited: 03 May 2013 15:41
Last Modified: 02 Feb 2019 15:58


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