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Synthetic applications of fluorous solid-phase extraction (F-SPE)

Zhang, W and Curran, DP (2006) Synthetic applications of fluorous solid-phase extraction (F-SPE). Tetrahedron, 62 (51). 11837 - 11865. ISSN 0040-4020

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Abstract

The synthetic applications of fluorous solid-phase extraction (F-SPE) for separation in small molecule synthesis, are discussed. F-SPE systems are consisted of 2 × 12 manifold and employs negative pressure, suitable for SPE cartridges with 2-10g silica gel. The predictability and generic 'fluorous/non-fluorous' nature of F-SPE make it suitable for use in research settings with single compounds. The automated sample loading capability of F-SPE allow it to handle solutions and slurries containing small amounts of solid. F-SPE is used in multiple steps, including tagging, reaction of tagged substrate, and detagging for synthesis of small molecules in oligonucleotide synthesis, peptide synthesis, proteomics, fluorous silica gel, and catalyst/reagent support applications. F-SPE is used for synthesis of fluorous reagents, fluorous reactants, catalysts and scavengers that scavenge undesired reaction components.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Zhang, W
Curran, DPcurran@pitt.eduCURRAN
Date: 18 December 2006
Date Type: Publication
Journal or Publication Title: Tetrahedron
Volume: 62
Number: 51
Page Range: 11837 - 11865
DOI or Unique Handle: 10.1016/j.tet.2006.08.051
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 0040-4020
Article Type: Review
PubMed Central ID: PMC2396515
PubMed ID: 18509513
Date Deposited: 15 May 2013 19:50
Last Modified: 02 Feb 2019 15:58
URI: http://d-scholarship.pitt.edu/id/eprint/18729

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