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Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin

Tangirala, RS and Antony, S and Agama, K and Pommier, Y and Anderson, BD and Bevins, R and Curran, DP (2006) Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin. Bioorganic and Medicinal Chemistry, 14 (18). 6202 - 6212. ISSN 0968-0896

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Analogs of the anti-tumor agent camptothecin with both closed E-rings (lactone and ether) and open E-rings (reduced acid, hydrazide, and protected Weinreb amide) have been prepared and tested in topoisomerase and cellular assays. The results provide insights into the structural features of the camptothecin E-ring that affect biological activity. © 2006 Elsevier Ltd. All rights reserved.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Tangirala, RS
Antony, S
Agama, K
Pommier, Y
Anderson, BD
Bevins, R
Curran, DPcurran@pitt.eduCURRAN
Date: 15 September 2006
Date Type: Publication
Journal or Publication Title: Bioorganic and Medicinal Chemistry
Volume: 14
Number: 18
Page Range: 6202 - 6212
DOI or Unique Handle: 10.1016/j.bmc.2006.05.073
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 0968-0896
MeSH Headings: Antineoplastic Agents--chemical synthesis; Antineoplastic Agents--chemistry; Antineoplastic Agents--pharmacology; Biological Assay; Camptothecin--analogs & derivatives; Camptothecin--chemical synthesis; Camptothecin--chemistry; Camptothecin--pharmacology; Cell Line, Tumor; Cell Proliferation--drug effects; DNA--drug effects; Drug Screening Assays, Antitumor; Enzyme Inhibitors--chemical synthesis; Enzyme Inhibitors--chemistry; Enzyme Inhibitors--pharmacology; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Topoisomerase Inhibitors
PubMed ID: 16793274
Date Deposited: 28 May 2013 15:27
Last Modified: 02 Feb 2019 15:58


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