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The Role of Monkey Prefrontal Cortex in Encoding Multiple Items in Working Memory

Konecky, Roma (2013) The Role of Monkey Prefrontal Cortex in Encoding Multiple Items in Working Memory. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Abstract

As we interact with our environment we are confronted with a constant barrage of sensory information that has to be stored and manipulated, often within a very short period of time. Working memory is the mechanism that supports the active maintenance and manipulation of information. The ability to hold and use information in memory is fundamental for cognition. Many complex behaviors require that we store several pieces of information in working memory. The requirement to remember several things at once is ubiquitous to most of our day to day interactions, yet very little is known about its neural basis.
To explore the neural mechanisms underlying multi-item working memory we recorded activity of neurons in the prefrontal cortex (PFC) of two monkeys while they performed a Sternberg working memory task. On each trial, three samples were presented in succession, each followed by a delay. The monkeys were required to hold these three samples in memory and recall one of them at the end of the trial. The monkeys’ performance decreased when working memory load was high. The monkeys’ also exhibited a recency effect where performance was better when the item to be recalled was the most recent.
PFC neurons were selective for the identity of the sample during the delay and selectivity tended to be the same regardless of the ordinal position of the sample. However, the strongest determinant of activity during each delay-period was the identity of the immediately preceding sample. The degradation of information about earlier samples stood in striking contrast to the monkeys’ intact ability to perform the task.
We found that the mean population firing rate and power in the gamma frequency band of the LFP increased as samples were presented successively. However, these effects were not related solely to memory load, because a similar pattern was present under the control condition in which the same sample was presented three times.
From the results of these experiments we conclude that although monkeys were capable of performing a task requiring the memory for multiple items, delay-period activity in prefrontal neurons cannot easily explain the monkey’s working memory performance.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Konecky, Romarok10@pitt.eduROK10
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairFiez, Juliefiez@pitt.eduFIEZ
Committee MemberOlson, Carlcolson@cnbc.cmu.eduOLSONC
Committee MemberBatista, Aaronapb10@pitt.eduAPB10
Committee MemberCho, Raymond Yryc2@pitt.eduRYC2
Committee MemberGandhi, Neerajneg8@pitt.eduNEG8
Committee MemberConstantinidis, Christoscconstan@wakehealth.edu
Date: 1 July 2013
Date Type: Publication
Defense Date: 19 December 2012
Approval Date: 1 July 2013
Submission Date: 20 May 2013
Access Restriction: 5 year -- Restrict access to University of Pittsburgh for a period of 5 years.
Number of Pages: 129
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Neuroscience
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: Gamma, LFP, induced response, working memory, non-human primates, prefrontal cortex.
Date Deposited: 01 Jul 2013 13:15
Last Modified: 19 Dec 2016 14:40
URI: http://d-scholarship.pitt.edu/id/eprint/18768

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