Wipf, P and Mo, T and Geib, SJ and Caridha, D and Dow, GS and Gerena, L and Roncal, N and Milner, EE
(2009)
Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine.
Organic and Biomolecular Chemistry, 7 (20).
4163 - 4165.
ISSN 1477-0520
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Abstract
Two novel SF5 analogs of the antimalarial agent mefloquine were synthesized in 5 steps and 10-23% overall yields and found to have improved activity and selectivity against malaria parasites. This work also represents the first report of SF5-substituted quinolines. © 2009 The Royal Society of Chemistry.
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Details
| Item Type: |
Article
|
| Status: |
Published |
| Creators/Authors: |
|
| Date: |
15 October 2009 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Organic and Biomolecular Chemistry |
| Volume: |
7 |
| Number: |
20 |
| Page Range: |
4163 - 4165 |
| DOI or Unique Handle: |
10.1039/b911483a |
| Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
| Refereed: |
Yes |
| ISSN: |
1477-0520 |
| MeSH Headings: |
Animals; Antimalarials--chemical synthesis; Antimalarials--chemistry; Antimalarials--pharmacology; Antimalarials--toxicity; Mefloquine--analogs & derivatives; Mefloquine--chemical synthesis; Mefloquine--pharmacology; Mefloquine--toxicity; Models, Molecular; Molecular Conformation; Plasmodium falciparum--drug effects |
| Other ID: |
NLM NIHMS224679, NLM PMC2929370 |
| PubMed Central ID: |
PMC2929370 |
| PubMed ID: |
19795052 |
| Date Deposited: |
07 Jun 2013 20:01 |
| Last Modified: |
22 Jun 2021 12:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/18848 |
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