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Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine

Wipf, P and Mo, T and Geib, SJ and Caridha, D and Dow, GS and Gerena, L and Roncal, N and Milner, EE (2009) Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine. Organic and Biomolecular Chemistry, 7 (20). 4163 - 4165. ISSN 1477-0520

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Abstract

Two novel SF5 analogs of the antimalarial agent mefloquine were synthesized in 5 steps and 10-23% overall yields and found to have improved activity and selectivity against malaria parasites. This work also represents the first report of SF5-substituted quinolines. © 2009 The Royal Society of Chemistry.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Wipf, Ppwipf@pitt.eduPWIPF
Mo, T
Geib, SJgeib@pitt.eduGEIB0000-0002-9160-7857
Caridha, D
Dow, GS
Gerena, L
Roncal, N
Milner, EE
Date: 15 October 2009
Date Type: Publication
Journal or Publication Title: Organic and Biomolecular Chemistry
Volume: 7
Number: 20
Page Range: 4163 - 4165
DOI or Unique Handle: 10.1039/b911483a
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 1477-0520
MeSH Headings: Animals; Antimalarials--chemical synthesis; Antimalarials--chemistry; Antimalarials--pharmacology; Antimalarials--toxicity; Mefloquine--analogs & derivatives; Mefloquine--chemical synthesis; Mefloquine--pharmacology; Mefloquine--toxicity; Models, Molecular; Molecular Conformation; Plasmodium falciparum--drug effects
Other ID: NLM NIHMS224679, NLM PMC2929370
PubMed Central ID: PMC2929370
PubMed ID: 19795052
Date Deposited: 07 Jun 2013 20:01
Last Modified: 02 Mar 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/18848

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