Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine

Wipf, P and Mo, T and Geib, SJ and Caridha, D and Dow, GS and Gerena, L and Roncal, N and Milner, EE (2009) Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine. Organic and Biomolecular Chemistry, 7 (20). 4163 - 4165. ISSN 1477-0520

[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)


Two novel SF5 analogs of the antimalarial agent mefloquine were synthesized in 5 steps and 10-23% overall yields and found to have improved activity and selectivity against malaria parasites. This work also represents the first report of SF5-substituted quinolines. © 2009 The Royal Society of Chemistry.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Wipf, Ppwipf@pitt.eduPWIPF
Mo, T
Geib, SJgeib@pitt.eduGEIB0000-0002-9160-7857
Caridha, D
Dow, GS
Gerena, L
Roncal, N
Milner, EE
Date: 15 October 2009
Date Type: Publication
Journal or Publication Title: Organic and Biomolecular Chemistry
Volume: 7
Number: 20
Page Range: 4163 - 4165
DOI or Unique Handle: 10.1039/b911483a
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 1477-0520
MeSH Headings: Animals; Antimalarials--chemical synthesis; Antimalarials--chemistry; Antimalarials--pharmacology; Antimalarials--toxicity; Mefloquine--analogs & derivatives; Mefloquine--chemical synthesis; Mefloquine--pharmacology; Mefloquine--toxicity; Models, Molecular; Molecular Conformation; Plasmodium falciparum--drug effects
Other ID: NLM NIHMS224679, NLM PMC2929370
PubMed Central ID: PMC2929370
PubMed ID: 19795052
Date Deposited: 07 Jun 2013 20:01
Last Modified: 22 Jun 2021 12:55


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item