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Anal human papillomavirus infection is associated with HIV acquisition in men who have sex with men

Chin-Hong, PV and Husnik, M and Cranston, RD and Colfax, G and Buchbinder, S and Da Costa, M and Darragh, T and Jones, D and Judson, F and Koblin, B and Mayer, KH and Palefsky, JM (2009) Anal human papillomavirus infection is associated with HIV acquisition in men who have sex with men. AIDS, 23 (9). 1135 - 1142. ISSN 0269-9370

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Abstract

OBJECTIVE:: Human papillomavirus (HPV) is a common sexually transmitted agent that causes anogenital cancer and precancer lesions that have an inflammatory infiltrate, may be friable and bleed. Our aim was to determine the association between anal HPV infection and HIV acquisition. DESIGN:: A prospective cohort study. METHODS:: We recruited 1409 HIV-negative men who have sex with men from a community-based setting in Boston, Denver, New York and San Francisco. We used Cox proportional hazards regression modeling and assessed the independent association of HPV infection with the rate of acquisition of HIV infection. RESULTS:: Of 1409 participants contributing 4375 person-years of follow-up, 51 HIV-seroconverted. The median number of HPV types in HPV-infected HIV-seroconverters was 2 (interquartile range 1-3) at the time of HIV seroconversion. After adjustment for sexual activity, substance use, occurrence of other sexually transmitted infections and demographic variables, there was evidence (P = 0.002) for the effect of infection with at least two HPV types (hazard ratio 3.5, 95% confidence interval 1.2-10.6) in HIV seroconversion. CONCLUSION:: Anal HPV infection is independently associated with HIV acquisition. Studies that incorporate high-resolution anoscopy to more accurately identify HPV-associated disease are needed to determine the relationship between HPV-associated disease and HIV seroconversion. © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Chin-Hong, PV
Husnik, M
Cranston, RDrdc27@pitt.eduRDC27
Colfax, G
Buchbinder, S
Da Costa, M
Darragh, T
Jones, D
Judson, F
Koblin, B
Mayer, KH
Palefsky, JM
Centers: Other Centers, Institutes, Offices, or Units > Center for LGBT Health Research
Date: 1 June 2009
Date Type: Publication
Journal or Publication Title: AIDS
Volume: 23
Number: 9
Page Range: 1135 - 1142
DOI or Unique Handle: 10.1097/qad.0b013e32832b4449
Schools and Programs: Graduate School of Public Health > Infectious Diseases and Microbiology
Refereed: Yes
ISSN: 0269-9370
MeSH Headings: Adult; Anus Diseases--virology; Boston; HIV Seropositivity--transmission; HIV Seropositivity--virology; HIV-1; Homosexuality, Male; Humans; Male; Middle Aged; New York; Papillomavirus Infections--transmission; Papillomavirus Infections--virology; Precancerous Conditions--virology; Prospective Studies; RNA, Viral; San Francisco
PubMed ID: 19390418
Date Deposited: 25 Jun 2013 19:38
Last Modified: 02 Feb 2019 16:57
URI: http://d-scholarship.pitt.edu/id/eprint/18975

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