Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

A retrospective clinical study of the treatment of high-grade anal dysplasia by infrared coagulation in a population of HIV-positive men who have sex with men

Cranston, RD and Hirschowitz, SL and Cortina, G and Moe, AA (2008) A retrospective clinical study of the treatment of high-grade anal dysplasia by infrared coagulation in a population of HIV-positive men who have sex with men. International Journal of STD and AIDS, 19 (2). 118 - 120. ISSN 0956-4624

[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)

Abstract

HIV-positive men who have sex with men (MSM) are at high risk of developing human papillomavirus-associated anal squamous cell cancer. Similar to the management of cervical dysplasia, clinicians are treating high-grade anal dysplasia to prevent progression to cancer. Initial treatments such as cold scalpel excision and electrofulguration have shown limited efficacy in a HIV-positive population. Infrared coagulation (IRC) is an outpatient treatment for high-grade anal dysplasia. This retrospective clinical study reports on 68 HIV-positive MSM with 78 biopsy proven high-grade anal lesions. Each lesion was treated with the IRC with re-biopsy of the treatment site a mean of 140 days later. Of the 74 evaluable lesions; 39 had anal intraepithelial neoplasia (AIN) 1, 20 had AIN 2, seven had AIN 3, and eight had normal epithelium. The IRC showed 64% efficacy per treated lesion and shows promise as a treatment modality for high-grade anal dysplasia in this population.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Cranston, RDrdc27@pitt.eduRDC27
Hirschowitz, SL
Cortina, G
Moe, AA
Centers: Other Centers, Institutes, Offices, or Units > Center for LGBT Health Research
Date: 1 February 2008
Date Type: Publication
Journal or Publication Title: International Journal of STD and AIDS
Volume: 19
Number: 2
Page Range: 118 - 120
DOI or Unique Handle: 10.1258/ijsa.2007.005665
Schools and Programs: School of Medicine > Infectious Diseases and Microbiology
Refereed: Yes
ISSN: 0956-4624
MeSH Headings: Anus Diseases--pathology; Anus Diseases--radiotherapy; Anus Neoplasms--prevention & control; Biopsy; HIV Infections--complications; HIV Seropositivity--complications; Homosexuality, Male; Humans; Infrared Rays--therapeutic use; Male; Retrospective Studies; Treatment Outcome
PubMed ID: 18334066
Date Deposited: 25 Jun 2013 19:42
Last Modified: 04 Feb 2019 23:55
URI: http://d-scholarship.pitt.edu/id/eprint/19013

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com


Actions (login required)

View Item View Item