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Fluorous synthesis of hydantoin-, piperazinedione-, and benzodiazepinedione-fused tricyclic and tetracyclic ring systems

Zhang, W and Lu, Y and Chen, CHT and Curran, DP and Geib, S (2006) Fluorous synthesis of hydantoin-, piperazinedione-, and benzodiazepinedione-fused tricyclic and tetracyclic ring systems. European Journal of Organic Chemistry (9). 2055 - 2059. ISSN 1434-193X

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Abstract

Fluorous proline derivatives generated from one-pot, three-component [3+2] cycloaddition of azomethine ylides are employed in different post-condensation reactions to form hydantoin-, piperazinedione-, and benzodiazepinedione-fused tricyclic and tetracyclic ring systems. High synthetic efficiency is achieved by conducting fast microwave reactions and purification by easy fluorous solid-phase extractions. Methods developed for these novel drug-like heterocyclic compounds can be applied to diversity-oriented library syntheses. © Wiley-VCH Verlag GmbH & Co. KGaA, 2006.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Zhang, W
Lu, Y
Chen, CHT
Curran, DPcurran@pitt.eduCURRAN
Geib, Sgeib@pitt.eduGEIB0000-0002-9160-7857
Date: 28 April 2006
Date Type: Publication
Journal or Publication Title: European Journal of Organic Chemistry
Number: 9
Page Range: 2055 - 2059
DOI or Unique Handle: 10.1002/ejoc.200600077
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 1434-193X
PubMed Central ID: PMC2423324
PubMed ID: 18542714
Date Deposited: 25 Jun 2013 16:00
Last Modified: 02 Feb 2019 15:59
URI: http://d-scholarship.pitt.edu/id/eprint/19097

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