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Mitochondrial DNA Copy Number Is Associated with Breast Cancer Risk

Thyagarajan, B and Wang, R and Nelson, H and Barcelo, H and Koh, WP and Yuan, JM (2013) Mitochondrial DNA Copy Number Is Associated with Breast Cancer Risk. PLoS ONE, 8 (6).

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Abstract

Mitochondrial DNA (mtDNA) copy number in peripheral blood is associated with increased risk of several cancers. However, data from prospective studies on mtDNA copy number and breast cancer risk are lacking. We evaluated the association between mtDNA copy number in peripheral blood and breast cancer risk in a nested case-control study of 183 breast cancer cases with pre-diagnostic blood samples and 529 individually matched controls among participants of the Singapore Chinese Health Study. The mtDNA copy number was measured using real time PCR. Conditional logistic regression analyses showed that there was an overall positive association between mtDNA copy number and breast cancer risk (P trend = 0.01). The elevated risk for higher mtDNA copy numbers was primarily seen for women with <3 years between blood draw and cancer diagnosis; ORs (95% CIs) for 2 nd , 3 rd , 4 th , and 5 th quintile of mtDNA copy number were 1.52 (0.61, 3.82), 2.52 (1.03, 6.12), 3.12 (1.31, 7.43), and 3.06 (1.25, 7.47), respectively, compared with the 1 st quintile (P trend = 0.004). There was no association between mtDNA copy number and breast cancer risk among women who donated a blood sample ≥3 years before breast cancer diagnosis (P trend = 0.41). This study supports a prospective association between increased mtDNA copy number and breast cancer risk that is dependent on the time interval between blood collection and breast cancer diagnosis. Future studies are warranted to confirm these findings and to elucidate the biological role of mtDNA copy number in breast cancer risk. © 2013 Thyagarajan et al.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Thyagarajan, B
Wang, Rrew59@pitt.eduREW59
Nelson, H
Barcelo, H
Koh, WP
Yuan, JMyuanj@pitt.eduYUANJ
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorBai, YidongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Centers: Other Centers, Institutes, or Units > Hillman Cancer Center
Date: 12 June 2013
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 8
Number: 6
DOI or Unique Handle: 10.1371/journal.pone.0065968
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
Date Deposited: 15 Jul 2013 20:15
Last Modified: 05 Mar 2019 00:56
URI: http://d-scholarship.pitt.edu/id/eprint/19208

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