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Triple hybrids of steroids, spiroketals, and oligopeptides as new biomolecular chimeras

Banerjee, A and Sergienko, E and Vasile, S and Gupta, V and Vuori, K and Wipf, P (2009) Triple hybrids of steroids, spiroketals, and oligopeptides as new biomolecular chimeras. Organic Letters, 11 (1). 65 - 68. ISSN 1523-7060

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Abstract

An oxidative enol ether rearrangement was the key methodology in the construction of steroid-spiroketal-RGD peptides. Biological studies demonstrated potent integrin CD11b/CD18 antagonistic effects. © 2009 American Chemical Society.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Banerjee, A
Sergienko, E
Vasile, S
Gupta, V
Vuori, K
Wipf, Ppwipf@pitt.eduPWIPF
Date: 1 January 2009
Date Type: Publication
Journal or Publication Title: Organic Letters
Volume: 11
Number: 1
Page Range: 65 - 68
DOI or Unique Handle: 10.1021/ol802247m
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 1523-7060
MeSH Headings: Antigens, CD11b--metabolism; Antigens, CD18--metabolism; Molecular Structure; Oligopeptides--chemistry; Oligopeptides--pharmacology; Oxidation-Reduction; Spiro Compounds--chemistry; Spiro Compounds--pharmacology; Stereoisomerism; Steroids--chemistry; Steroids--pharmacology; Structure-Activity Relationship
PubMed ID: 19067551
Date Deposited: 03 Jul 2013 14:56
Last Modified: 13 Oct 2017 18:55
URI: http://d-scholarship.pitt.edu/id/eprint/19220

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