Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

The prevalence, and predictive value, of abnormal anal cytology to diagnose anal dysplasia in a population of HIV-positive men who have sex with men

Cranston, RD and Hart, SD and Gornbein, JA and Hirschowitz, SL and Cortina, G and Moe, AA (2007) The prevalence, and predictive value, of abnormal anal cytology to diagnose anal dysplasia in a population of HIV-positive men who have sex with men. International Journal of STD and AIDS, 18 (2). 77 - 80. ISSN 0956-4624

[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)

Abstract

Due to the increasing incidence of anal cancer in HIV-positive men who have sex with men, and the potential to detect and treat high-grade anal dysplasia - the putative anal cancer precursor - we have introduced an anal cytology screening service. Patients with abnormal anal cytology have follow-up high-resolution anoscopy (HRA) with biopsy of lesions clinically suspicious for high-grade dysplasia. In total, 244 men were screened and 235 (96%) of the samples were adequate for cytological interpretation using the Bethesda 2001 system. One hundred and sixty-four (67%) men had abnormal anal cytology, and 93 of them had follow-up HRA and anal biopsy. The positive predictive value for any anal cytological abnormality to predict any degree of anal dysplasia was 95.7±2.1%, and for any anal cytological abnormality to predict high-grade anal dysplasia was 55.9±5.1%. Abnormal anal cytology was highly predicative of anal dysplasia on biopsy.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Cranston, RDrdc27@pitt.eduRDC27
Hart, SD
Gornbein, JA
Hirschowitz, SL
Cortina, G
Moe, AA
Centers: Other Centers, Institutes, or Units > Center for LGBT Health Research
Date: 1 February 2007
Date Type: Publication
Journal or Publication Title: International Journal of STD and AIDS
Volume: 18
Number: 2
Page Range: 77 - 80
DOI or Unique Handle: 10.1258/095646207779949772
Schools and Programs: School of Medicine > Infectious Diseases and Microbiology
Refereed: Yes
ISSN: 0956-4624
MeSH Headings: AIDS-Related Opportunistic Infections--diagnosis; AIDS-Related Opportunistic Infections--epidemiology; Adult; Aged; Anal Canal--pathology; Anus Neoplasms--diagnosis; Anus Neoplasms--epidemiology; Biopsy; Carcinoma, Squamous Cell--diagnosis; Carcinoma, Squamous Cell--epidemiology; Cytological Techniques; HIV Infections--complications; HIV Infections--epidemiology; Homosexuality, Male; Humans; Male; Middle Aged; Predictive Value of Tests; Prevalence
PubMed ID: 17331275
Date Deposited: 15 Jul 2013 20:08
Last Modified: 04 Feb 2019 23:55
URI: http://d-scholarship.pitt.edu/id/eprint/19233

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com


Actions (login required)

View Item View Item