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The prevalence, and predictive value, of abnormal anal cytology to diagnose anal dysplasia in a population of HIV-positive men who have sex with men

Cranston, RD and Hart, SD and Gornbein, JA and Hirschowitz, SL and Cortina, G and Moe, AA (2007) The prevalence, and predictive value, of abnormal anal cytology to diagnose anal dysplasia in a population of HIV-positive men who have sex with men. International Journal of STD and AIDS, 18 (2). 77 - 80. ISSN 0956-4624

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Abstract

Due to the increasing incidence of anal cancer in HIV-positive men who have sex with men, and the potential to detect and treat high-grade anal dysplasia - the putative anal cancer precursor - we have introduced an anal cytology screening service. Patients with abnormal anal cytology have follow-up high-resolution anoscopy (HRA) with biopsy of lesions clinically suspicious for high-grade dysplasia. In total, 244 men were screened and 235 (96%) of the samples were adequate for cytological interpretation using the Bethesda 2001 system. One hundred and sixty-four (67%) men had abnormal anal cytology, and 93 of them had follow-up HRA and anal biopsy. The positive predictive value for any anal cytological abnormality to predict any degree of anal dysplasia was 95.7±2.1%, and for any anal cytological abnormality to predict high-grade anal dysplasia was 55.9±5.1%. Abnormal anal cytology was highly predicative of anal dysplasia on biopsy.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Cranston, RDrdc27@pitt.eduRDC27
Hart, SD
Gornbein, JA
Hirschowitz, SL
Cortina, G
Moe, AA
Centers: Other Centers, Institutes, Offices, or Units > Center for LGBT Health Research
Date: 1 February 2007
Date Type: Publication
Journal or Publication Title: International Journal of STD and AIDS
Volume: 18
Number: 2
Page Range: 77 - 80
DOI or Unique Handle: 10.1258/095646207779949772
Schools and Programs: School of Medicine > Infectious Diseases and Microbiology
Refereed: Yes
ISSN: 0956-4624
MeSH Headings: AIDS-Related Opportunistic Infections--diagnosis; AIDS-Related Opportunistic Infections--epidemiology; Adult; Aged; Anal Canal--pathology; Anus Neoplasms--diagnosis; Anus Neoplasms--epidemiology; Biopsy; Carcinoma, Squamous Cell--diagnosis; Carcinoma, Squamous Cell--epidemiology; Cytological Techniques; HIV Infections--complications; HIV Infections--epidemiology; Homosexuality, Male; Humans; Male; Middle Aged; Predictive Value of Tests; Prevalence
PubMed ID: 17331275
Date Deposited: 15 Jul 2013 20:08
Last Modified: 04 Feb 2019 23:55
URI: http://d-scholarship.pitt.edu/id/eprint/19233

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