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The relationship between methamphetamine and popper use and risk of HIV seroconversion in the multicenter AIDS cohort study

Plankey, MW and Ostrow, DG and Stall, R and Cox, C and Li, X and Peck, JA and Jacobson, LP (2007) The relationship between methamphetamine and popper use and risk of HIV seroconversion in the multicenter AIDS cohort study. Journal of Acquired Immune Deficiency Syndromes, 45 (1). 85 - 92. ISSN 1525-4135

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Abstract

BACKGROUND: The association between methamphetamine use and HIV seroconversion for men who have sex with men (MSM) was examined using longitudinal data from the Multicenter AIDS Cohort Study. METHODS: Seronegative (n = 4003) men enrolled in 1984 to 1985, 1987 to 1991, and 2001 to 2003 were identified. Recent methamphetamine and popper use was determined at the current or previous visit. Time to HIV seroconversion was the outcome of interest. Covariates included race/ethnicity, cohort, study site, educational level, number of sexual partners, number of unprotected insertive anal sexual partners, number of unprotected receptive anal sexual partners, insertive rimming, cocaine use at the current or last visit, ecstasy use at the current or last visit, any needle use since the last visit, Center for Epidemiologic Study of Depression symptom checklist score >16 since the last visit, and alcohol consumption. RESULTS: After adjusting for covariates, there was a 1.46 (95% confidence interval [CI]: 1.12 to 1.92) increased relative hazard of HIV seroconversion associated with methamphetamine use. The relative hazard associated with popper use was 2.10 (95% CI: 1.63 to 2.70). The relative hazard of HIV seroconversion increased with the number of unprotected receptive anal sexual partners, ranging from 1.87 (95% CI: 1.40 to 2.51) for 1 partner to 9.32 (95% CI: 6.21 to 13.98) for 5+ partners. The joint relative hazard for methamphetamine and popper use was 3.05 (95% CI: 2.12 to 4.37). There was a significant joint relative hazard for methamphetamine use and number of unprotected receptive anal sexual partners of 2.71 (95% CI: 1.81 to 4.04) for men with 1 unprotected receptive anal sexual partner, which increased in a dose-dependent manner for >1 partners. CONCLUSIONS: Further examination of the mechanisms underlying the synergism of drug use and sexual risk behaviors on rates of HIV seroconversion is necessary for the development of new targeted HIV prevention strategies for nonmonogamous drug-using MSM. © 2007 Lippincott Williams & Wilkins, Inc.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Plankey, MW
Ostrow, DG
Stall, Rrstall@pitt.eduRSTALL
Cox, C
Li, X
Peck, JA
Jacobson, LP
Centers: Other Centers, Institutes, or Units > Center for LGBT Health Research
Date: 1 May 2007
Date Type: Publication
Journal or Publication Title: Journal of Acquired Immune Deficiency Syndromes
Volume: 45
Number: 1
Page Range: 85 - 92
DOI or Unique Handle: 10.1097/qai.0b013e3180417c99
Schools and Programs: Graduate School of Public Health > Behavioral and Community Health Sciences
Refereed: Yes
ISSN: 1525-4135
MeSH Headings: Acquired Immunodeficiency Syndrome--epidemiology; Acquired Immunodeficiency Syndrome--transmission; Adult; Cohort Studies; HIV Seropositivity--epidemiology; HIV Seropositivity--transmission; Homosexuality, Male; Humans; Male; Methamphetamine; Multicenter Studies as Topic; Multivariate Analysis; N-Methyl-3,4-methylenedioxyamphetamine; Risk Factors; Sexual Behavior; Sexual Partners; Substance-Related Disorders--epidemiology; Time Factors
Other ID: NLM NIHMS410308, NLM PMC3486782
PubMed Central ID: PMC3486782
PubMed ID: 17325605
Date Deposited: 15 Jul 2013 20:00
Last Modified: 02 Feb 2019 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/19239

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