Keinan, S and Paquette, WD and Skoko, JJ and Beratan, DN and Yang, W and Shinde, S and Johnston, PA and Lazo, JS and Wipf, P
(2008)
Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B.
Organic and Biomolecular Chemistry, 6 (18).
3256 - 3263.
ISSN 1477-0520
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Abstract
Quinoid inhibitors of Cdc25B were designed based on the Linear Combination of Atomic Potentials (LCAP) methodology. In contrast to a published hypothesis, the biological activities and hydrogen peroxide generation in reducing media of three synthetic models did not correlate with the quinone half-wave potential, E1/2. © 2008 The Royal Society of Chemistry.
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Details
Item Type: |
Article
|
Status: |
Published |
Creators/Authors: |
|
Date: |
3 October 2008 |
Date Type: |
Publication |
Journal or Publication Title: |
Organic and Biomolecular Chemistry |
Volume: |
6 |
Number: |
18 |
Page Range: |
3256 - 3263 |
DOI or Unique Handle: |
10.1039/b806712k |
Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
Refereed: |
Yes |
ISSN: |
1477-0520 |
MeSH Headings: |
Cell Line, Tumor; Cell Survival--drug effects; Combinatorial Chemistry Techniques; Computer Simulation; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors--chemical synthesis; Enzyme Inhibitors--chemistry; Enzyme Inhibitors--pharmacology; Humans; Hydrogen Peroxide; Molecular Structure; Oxidation-Reduction--drug effects; Quinones--chemical synthesis; Quinones--chemistry; Quinones--pharmacology; Structure-Activity Relationship; Substrate Specificity; cdc25 Phosphatases--antagonists & inhibitors; cdc25 Phosphatases--metabolism |
Other ID: |
NLM NIHMS123614, NLM PMC2752828 |
PubMed Central ID: |
PMC2752828 |
PubMed ID: |
18802630 |
Date Deposited: |
15 Jul 2013 19:55 |
Last Modified: |
22 Jun 2021 12:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/19276 |
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