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Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation

Wright, CM and Chovatiya, RJ and Jameson, NE and Turner, DM and Zhu, G and Werner, S and Huryn, DM and Pipas, JM and Day, BW and Wipf, P and Brodsky, JL (2008) Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation. Bioorganic and Medicinal Chemistry, 16 (6). 3291 - 3301. ISSN 0968-0896

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Abstract

The Hsp70 molecular chaperones are ATPases that play critical roles in the pathogenesis of many human diseases, including breast cancer. Hsp70 ATP hydrolysis is relatively weak but is stimulated by J domain-containing proteins. We identified pyrimidinone-peptoid hybrid molecules that inhibit cell proliferation with greater potency than previously described Hsp70 modulators. In many cases, anti-proliferative activity correlated with inhibition of J domain stimulation of Hsp70. © 2007 Elsevier Ltd. All rights reserved.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Wright, CM
Chovatiya, RJ
Jameson, NE
Turner, DM
Zhu, G
Werner, S
Huryn, DM
Pipas, JMpipas@pitt.eduPIPAS
Day, BW
Wipf, Ppwipf@pitt.eduPWIPF
Brodsky, JLjbrodsky@pitt.eduJBRODSKY0000-0002-6984-8486
Date: 15 March 2008
Date Type: Publication
Journal or Publication Title: Bioorganic and Medicinal Chemistry
Volume: 16
Number: 6
Page Range: 3291 - 3301
DOI or Unique Handle: 10.1016/j.bmc.2007.12.014
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 0968-0896
MeSH Headings: Adenosine Triphosphatases--metabolism; Breast Neoplasms--drug therapy; Cell Proliferation--drug effects; Female; HSP70 Heat-Shock Proteins--antagonists & inhibitors; Humans; Molecular Chaperones--drug effects; Peptoids--chemistry; Peptoids--pharmacology; Pyrimidinones--chemistry; Pyrimidinones--pharmacology
Other ID: NLM NIHMS45414, NLM PMC2330198
PubMed Central ID: PMC2330198
PubMed ID: 18164205
Date Deposited: 22 Jul 2013 19:07
Last Modified: 02 Feb 2019 16:57
URI: http://d-scholarship.pitt.edu/id/eprint/19348

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