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Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation

Wright, CM and Chovatiya, RJ and Jameson, NE and Turner, DM and Zhu, G and Werner, S and Huryn, DM and Pipas, JM and Day, BW and Wipf, P and Brodsky, JL (2008) Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation. Bioorganic and Medicinal Chemistry, 16 (6). 3291 - 3301. ISSN 0968-0896

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The Hsp70 molecular chaperones are ATPases that play critical roles in the pathogenesis of many human diseases, including breast cancer. Hsp70 ATP hydrolysis is relatively weak but is stimulated by J domain-containing proteins. We identified pyrimidinone-peptoid hybrid molecules that inhibit cell proliferation with greater potency than previously described Hsp70 modulators. In many cases, anti-proliferative activity correlated with inhibition of J domain stimulation of Hsp70. © 2007 Elsevier Ltd. All rights reserved.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Wright, CM
Chovatiya, RJ
Jameson, NE
Turner, DM
Zhu, G
Werner, S
Huryn, DM
Pipas, JMpipas@pitt.eduPIPAS
Day, BW
Wipf, Ppwipf@pitt.eduPWIPF
Brodsky, JLjbrodsky@pitt.eduJBRODSKY0000-0002-6984-8486
Date: 15 March 2008
Date Type: Publication
Journal or Publication Title: Bioorganic and Medicinal Chemistry
Volume: 16
Number: 6
Page Range: 3291 - 3301
DOI or Unique Handle: 10.1016/j.bmc.2007.12.014
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 0968-0896
MeSH Headings: Adenosine Triphosphatases--metabolism; Breast Neoplasms--drug therapy; Cell Proliferation--drug effects; Female; HSP70 Heat-Shock Proteins--antagonists & inhibitors; Humans; Molecular Chaperones--drug effects; Peptoids--chemistry; Peptoids--pharmacology; Pyrimidinones--chemistry; Pyrimidinones--pharmacology
Other ID: NLM NIHMS45414, NLM PMC2330198
PubMed Central ID: PMC2330198
PubMed ID: 18164205
Date Deposited: 22 Jul 2013 19:07
Last Modified: 02 Feb 2019 16:57


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