Song, Chengyi
(2013)
DEVELOPMENT OF PEPTIDE-BASED METHODS FOR CONTROLLING THE STRUCTURES, COMPOSITIONS, AND PROPERTIES OF COMPLEX
NANOPARTICLE SUPERSTRUCTURES.
Doctoral Dissertation, University of Pittsburgh.
(Unpublished)
Abstract
This dissertation describes the development of a nanoparticle assembly methodology based on the use of peptide conjugate molecules. The aim of this research was to explore how this methodology could be used to control the structure, metrics, and properties of product nanoparticle superstructures.
Specifically, this document describes mechanistic studies aimed at understanding the key factors that govern the nanoparticle synthesis and assembly process. Using what we learned from these studies, we prepared high-quality helical nanoparticle superstructures and studied their chirooptical properties. We coupled theory and experiment to show how tuning the metrics and structure of the helices results in predictable and tailorable circular dichroism (CD) properties. We also describe how the composition of the peptide conjugate can influence both the structure of the nanoparticle assembly and detail how peptide conjugates can be utilized to prepare ‘hollow’ sub-100nm gold nanoparticle spheres. Finally, to expand the composition scope of our newly developed methodology, we present a new cobalt-binding peptide conjugate, which could be used to direct the synthesis and assembly of hollow CoPt nanospherical superstructures exhibiting electrocatalytic activity for methanol oxidation.
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Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
|
| Date: |
30 September 2013 |
| Date Type: |
Publication |
| Defense Date: |
8 August 2013 |
| Approval Date: |
30 September 2013 |
| Submission Date: |
27 July 2013 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
234 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
| Degree: |
PhD - Doctor of Philosophy |
| Thesis Type: |
Doctoral Dissertation |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
nanoparticle assembly; peptide assembly; self-assembly; chiral nanostructures;plasmonic nanoparticle. |
| Date Deposited: |
30 Sep 2013 16:09 |
| Last Modified: |
15 Nov 2016 14:14 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/19485 |
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