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Ring-closing metathesis approach to dictyostatin

Kangani, CO and Brückner, AM and Curran, DP (2005) Ring-closing metathesis approach to dictyostatin. Organic Letters, 7 (3). 379 - 382. ISSN 1523-7060

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(Chemical Equation Presented) An esterification/ring-closing metathesis approach to dictyostatin and discodermolide is introduced. The approach provides for facile fragment coupling of two main segments of these natural products at the C10-C11 alkene with high to complete Z-selectivity.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Kangani, CO
Brückner, AM
Curran, DPcurran@pitt.eduCURRAN
Date: 3 February 2005
Date Type: Publication
Journal or Publication Title: Organic Letters
Volume: 7
Number: 3
Page Range: 379 - 382
DOI or Unique Handle: 10.1021/ol0478279
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 1523-7060
MeSH Headings: Alkanes--chemistry; Carbamates--chemistry; Esters--chemistry; Indicators and Reagents; Lactones--chemistry; Macrolides--chemical synthesis; Molecular Conformation; Oxidation-Reduction; Pyrones--chemistry; Structure-Activity Relationship
PubMed ID: 15673244
Date Deposited: 07 Aug 2013 14:48
Last Modified: 15 Oct 2017 06:55


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