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Vermis-cingulate cortex interconnections: A cerebro-cerebellar circuit in the rat.

Galgiani, Jessica E (2013) Vermis-cingulate cortex interconnections: A cerebro-cerebellar circuit in the rat. Master's Thesis, University of Pittsburgh. (Unpublished)

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Classic observations suggest that the cerebellum is involved in affect and its expression. The neural substrate that mediates this behavior has been unclear. Recently, Sacchetti and his colleagues demonstrated that lesions involving portions of lobules V and VI in the rat cerebellar vermis abolish the consolidation of fear conditioning (Sacchetti et al., 2002). To gain some insight into the circuitry that mediates this effect, we used retrograde transneuronal transport of rabies virus (RV) to examine inputs to and outputs from vermal lobule VI. We found that the cingulate cortex (Cg) is the origin of a substantial disynaptic projection to lobule VI. In addition, we found that the fastigial nucleus and portions of vermal lobule VI are the origin of substantial disynaptic and trisynaptic projections to Cg. These observations suggest that a closed-loop circuit exists between vermal lobule VI and Cg. Furthermore, our results raise the possibility that aspects of fear conditioning, in particular, and emotion, in general may be influenced by this cerebro-cerebellar circuit.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Galgiani, Jessica
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee MemberTurner, Robert Srturner@pitt.eduRTURNER
Committee MemberStrick, Peter Lstrickp@pitt.eduSTRICKP
Committee ChairRinaman, Linda Mrinaman@pitt.eduRINAMAN
Date: 22 September 2013
Date Type: Publication
Defense Date: 24 June 2013
Approval Date: 22 September 2013
Submission Date: 11 August 2013
Access Restriction: 5 year -- Restrict access to University of Pittsburgh for a period of 5 years.
Number of Pages: 37
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Neuroscience
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Cerebellum, vermis, Rabies Virus, fear conditioning
Date Deposited: 22 Sep 2013 21:39
Last Modified: 22 Sep 2018 05:15


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