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Electrophysiological Heterogeneity of Fast-Spiking Interneurons: Chandelier versus Basket Cells

Povysheva, NV and Zaitsev, AV and Gonzalez-Burgos, G and Lewis, DA (2013) Electrophysiological Heterogeneity of Fast-Spiking Interneurons: Chandelier versus Basket Cells. PLoS ONE, 8 (8).

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In the prefrontal cortex, parvalbumin-positive inhibitory neurons play a prominent role in the neural circuitry that subserves working memory, and alterations in these neurons contribute to the pathophysiology of schizophrenia. Two morphologically distinct classes of parvalbumin neurons that target the perisomatic region of pyramidal neurons, chandelier cells (ChCs) and basket cells (BCs), are generally thought to have the same "fast-spiking" phenotype, which is characterized by a short action potential and high frequency firing without adaptation. However, findings from studies in different species suggest that certain electrophysiological membrane properties might differ between these two cell classes. In this study, we assessed the physiological heterogeneity of fast-spiking interneurons as a function of two factors: species (macaque monkey vs. rat) and morphology (chandelier vs. basket). We showed previously that electrophysiological membrane properties of BCs differ between these two species. Here, for the first time, we report differences in ChCs membrane properties between monkey and rat. We also found that a number of membrane properties differentiate ChCs from BCs. Some of these differences were species-independent (e.g., fast and medium afterhyperpolarization, firing frequency, and depolarizing sag), whereas the differences in the first spike latency between ChCs and BCs were species-specific. Our findings indicate that different combinations of electrophysiological membrane properties distinguish ChCs from BCs in rodents and primates. Such electrophysiological differences between ChCs and BCs likely contribute to their distinctive roles in cortical circuitry in each species. © 2013 Povysheva et al.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Povysheva, NVnvp1@pitt.eduNVP1
Zaitsev, AV
Gonzalez-Burgos, Ggburgos@pitt.eduGBURGOS0000-0002-1650-8111
Lewis, DAtnplewis@pitt.eduTNPLEWIS
Date: 12 August 2013
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 8
Number: 8
DOI or Unique Handle: 10.1371/journal.pone.0070553
Schools and Programs: Dietrich School of Arts and Sciences > Neuroscience
School of Medicine > Psychiatry
Refereed: Yes
Date Deposited: 23 Sep 2013 17:23
Last Modified: 02 Feb 2019 16:56


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