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Network-Level Structural Abnormalities of Cerebral Cortex in Type 1 Diabetes Mellitus

Lyoo, IK and Yoon, S and Renshaw, PF and Hwang, J and Bae, S and Musen, G and Kim, JE and Bolo, N and Jeong, HS and Simonson, DC and Lee, SH and Weinger, K and Jung, JJ and Ryan, CM and Choi, Y and Jacobson, AM (2013) Network-Level Structural Abnormalities of Cerebral Cortex in Type 1 Diabetes Mellitus. PLoS ONE, 8 (8).

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Abstract

Type 1 diabetes mellitus (T1DM) usually begins in childhood and adolescence and causes lifelong damage to several major organs including the brain. Despite increasing evidence of T1DM-induced structural deficits in cortical regions implicated in higher cognitive and emotional functions, little is known whether and how the structural connectivity between these regions is altered in the T1DM brain. Using inter-regional covariance of cortical thickness measurements from high-resolution T1-weighted magnetic resonance data, we examined the topological organizations of cortical structural networks in 81 T1DM patients and 38 healthy subjects. We found a relative absence of hierarchically high-level hubs in the prefrontal lobe of T1DM patients, which suggests ineffective top-down control of the prefrontal cortex in T1DM. Furthermore, inter-network connections between the strategic/executive control system and systems subserving other cortical functions including language and mnemonic/emotional processing were also less integrated in T1DM patients than in healthy individuals. The current results provide structural evidence for T1DM-related dysfunctional cortical organization, which specifically underlie the top-down cognitive control of language, memory, and emotion. © 2013 Lyoo et al.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Lyoo, IK
Yoon, S
Renshaw, PF
Hwang, J
Bae, S
Musen, G
Kim, JE
Bolo, N
Jeong, HS
Simonson, DC
Lee, SH
Weinger, K
Jung, JJ
Ryan, CMcmr14@pitt.eduCMR14
Choi, Y
Jacobson, AM
Date: 23 August 2013
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 8
Number: 8
DOI or Unique Handle: 10.1371/journal.pone.0071304
Schools and Programs: School of Medicine > Psychiatry
Refereed: Yes
Date Deposited: 23 Sep 2013 18:49
Last Modified: 02 Feb 2019 16:58
URI: http://d-scholarship.pitt.edu/id/eprint/19791

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