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Separation-friendly Mitsunobu reactions: A microcosm of recent developments in separation strategies

Dandapani, S and Curran, DP (2004) Separation-friendly Mitsunobu reactions: A microcosm of recent developments in separation strategies. Chemistry - A European Journal, 10 (13). 3130 - 3138. ISSN 0947-6539

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The Mitsunobu reaction is famous for its scope and power, but infamous for its separation headaches. Typically, the target product is enticed away from the reagent-derived byproducts by careful chromatography. The use of polymer-bound Mitsunobu reagents solves only half of the problem, because polymer-bound diethyl azodicarboxylate (DEAD) and phosphine reagents cannot be employed simultaneously. This article classifies, compares, and contrasts various emerging strategies for product isolation in Mitsunobu reactions. Because so many different strategies have been used, the Mitsunobu reaction is a microcosm for the new field of strategy level separations.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Dandapani, S
Curran, DPcurran@pitt.eduCURRAN
Date: 5 July 2004
Date Type: Publication
Journal or Publication Title: Chemistry - A European Journal
Volume: 10
Number: 13
Page Range: 3130 - 3138
DOI or Unique Handle: 10.1002/chem.200400363
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 0947-6539
Article Type: Review
MeSH Headings: Alcohols--chemistry; Alcohols--isolation & purification; Azo Compounds--chemistry; Azo Compounds--isolation & purification; Chlorophenols--chemistry; Chlorophenols--isolation & purification; Combinatorial Chemistry Techniques--methods; Dicarboxylic Acids--chemistry; Dicarboxylic Acids--isolation & purification; Hydrazines--chemistry; Hydrazines--isolation & purification; Organophosphorus Compounds--chemistry; Organophosphorus Compounds--isolation & purification
PubMed ID: 15224321
Date Deposited: 18 Oct 2013 17:38
Last Modified: 15 Oct 2017 06:55


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