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Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system

Wipf, P and Lynch, SM and Powis, G and Birmingham, A and Englund, EE (2005) Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system. Organic and Biomolecular Chemistry, 3 (21). 3880 - 3882. ISSN 1477-0520

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A series of palmarumycin prodrugs and water-soluble analogs has been synthesized and assayed for inhibition of the thioredoxin-thioredoxin reductase system. Increased aqueous solubility led to an improved in vivo activity profile. © The Royal Society of Chemistry 2005.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Wipf, Ppwipf@pitt.eduPWIPF
Lynch, SM
Powis, G
Birmingham, A
Englund, EE
Date: 7 November 2005
Date Type: Publication
Journal or Publication Title: Organic and Biomolecular Chemistry
Volume: 3
Number: 21
Page Range: 3880 - 3882
DOI or Unique Handle: 10.1039/b510718k
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 1477-0520
MeSH Headings: Antineoplastic Agents--chemical synthesis; Antineoplastic Agents--pharmacology; Cell Line, Tumor; Cell Proliferation--drug effects; Drug Screening Assays, Antitumor; Humans; Naphthalenes--chemistry; Naphthalenes--pharmacology; Prodrugs--chemical synthesis; Prodrugs--pharmacology; Solubility; Spiro Compounds--chemistry; Spiro Compounds--pharmacology; Structure-Activity Relationship; Thioredoxin-Disulfide Reductase--antagonists & inhibitors; Thioredoxins--antagonists & inhibitors
PubMed ID: 16240002
Date Deposited: 30 Oct 2013 16:48
Last Modified: 02 Feb 2019 15:56


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