Wipf, P and Lynch, SM and Powis, G and Birmingham, A and Englund, EE
(2005)
Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system.
Organic and Biomolecular Chemistry, 3 (21).
3880 - 3882.
ISSN 1477-0520
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Abstract
A series of palmarumycin prodrugs and water-soluble analogs has been synthesized and assayed for inhibition of the thioredoxin-thioredoxin reductase system. Increased aqueous solubility led to an improved in vivo activity profile. © The Royal Society of Chemistry 2005.
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Details
Item Type: |
Article
|
Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
---|
Wipf, P | pwipf@pitt.edu | PWIPF | | Lynch, SM | | | | Powis, G | | | | Birmingham, A | | | | Englund, EE | | | |
|
Date: |
7 November 2005 |
Date Type: |
Publication |
Journal or Publication Title: |
Organic and Biomolecular Chemistry |
Volume: |
3 |
Number: |
21 |
Page Range: |
3880 - 3882 |
DOI or Unique Handle: |
10.1039/b510718k |
Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
Refereed: |
Yes |
ISSN: |
1477-0520 |
MeSH Headings: |
Antineoplastic Agents--chemical synthesis; Antineoplastic Agents--pharmacology; Cell Line, Tumor; Cell Proliferation--drug effects; Drug Screening Assays, Antitumor; Humans; Naphthalenes--chemistry; Naphthalenes--pharmacology; Prodrugs--chemical synthesis; Prodrugs--pharmacology; Solubility; Spiro Compounds--chemistry; Spiro Compounds--pharmacology; Structure-Activity Relationship; Thioredoxin-Disulfide Reductase--antagonists & inhibitors; Thioredoxins--antagonists & inhibitors |
PubMed ID: |
16240002 |
Date Deposited: |
30 Oct 2013 16:48 |
Last Modified: |
02 Feb 2019 15:56 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/19936 |
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