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Relevance of meiotic recombination in public health: lessons from the monodelphis domestica

Jacoby, Kimberly C (2013) Relevance of meiotic recombination in public health: lessons from the monodelphis domestica. Master Essay, University of Pittsburgh.

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Abstract

Errors in meiotic recombination and its sequelae are one of the fundamental causes of newborn morbidity and mortality and results in a significant burden on public health. Current dogma regarding mechanisms of human meiosis states that recombination must occur in order for chromosomes to segregate properly. Recently, investigators have reported a positive correlation between reduced or absent recombination on chromosome 21 and a reduced genome-wide recombination rate. Although recombination rates vary among individuals, successful disjunction is not inextricably tied to recombination rate, and successful meiotic disjunction can occur in the absence of recombination. In addition to individual variation, recombination rates vary between genders and among different species. To better explore relationships between nondisjunction, disjunction and recombination, studies of an animal model with inherently lower genome-wide rates of recombination are useful. This project assesses the role of meiotic recombination in disjunction and nondisjunction based on studies of humans and Monodelphis domestica. Understanding the mechanisms that influence correct chromosomal segregation during meiosis could lead to methods of prophylaxis that could reduce the occurrence of such errors, and subsequently reduce newborn morbidity and mortality.


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Details

Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Jacoby, Kimberly Ckjacoby@pitt.eduKJACOBY
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
Committee ChairKammerer, Candacecmk3@pitt.eduCMK3UNSPECIFIED
Committee MemberDiergaarde, Brendabbd3@pitt.eduBBD3UNSPECIFIED
Date: November 2013
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Publisher: University of Pittsburgh
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Human Genetics
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: No
Date Deposited: 20 May 2015 20:54
Last Modified: 30 Oct 2018 14:01
URI: http://d-scholarship.pitt.edu/id/eprint/19995

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