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Repeated adipokine measures in HIV infected men on HAART: assessing change in adipokine levels and their correlation with lipids over the course of HIV progression and treatment

Oakley, Jennifer (2014) Repeated adipokine measures in HIV infected men on HAART: assessing change in adipokine levels and their correlation with lipids over the course of HIV progression and treatment. Master Essay, University of Pittsburgh.

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Abstract

Background: Treatment with highly active antiretroviral therapy (HAART) slows the progression of Human Immunodeficiency Virus (HIV) thus extending the life of people infected with HIV. However, an increased incidence in dyslipidemia seen with HAART use may lead to increased cardiovascular disease (CVD) risk. Objective: To characterize the relationship between lipid and adipokine serum levels in HIV-infected men on HAART across disease progression and treatment at 5 time points: preseroconversion, postseroconversion/pre-HAART, HAART initiation and two post HAART visits. Methods: We measured serum levels of leptin, adiponectin, resistin, IL-6 and TNF-alpha in 54 HIV-infected men from the Multicenter AIDS Cohort Study (MACS). Mixed model repeated measures ANOVA and bootstrap correlation quantify the relationships between the adipokine and lipid levels. Results: Adiponectin decreased post-seroconversion and post HAART initiation and remained lower throughout the HAART visits. TNF-alpha and IL-6 increased at seroconversion and HAART initiation and then decreased with continued therapy. Adiponectin and HDL-C were significantly positively correlated at every time point except post-seroconversion. The other adipokines were not correlated with any of the lipid measures. Conclusions: The relationship between adiponectin and HDL-C is changed with HIV infection and HAART; potentially reflecting metabolic and cardiovascular complications that seen during the course of the disease-treatment process. Public health significance: Exploring the role adipokines play in metabolic pathway disturbances in relationship to HIV infection and HAART has important public health significance by elucidating potential leading to drug therapy targets to reduce CVD risks.


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Details

Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Oakley, Jennifer
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
Committee ChairBertolet, Marniebertoletm@edc.pitt.eduMHB12UNSPECIFIED
Committee MemberBarinas-Mitchell, Emmabarinas@edc.pitt.eduEJB4UNSPECIFIED
Committee MemberMartinson, Jeremy Jjmartins@pitt.eduJMARTINSUNSPECIFIED
Date: 2 May 2014
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Publisher: University of Pittsburgh
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Epidemiology
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Uncontrolled Keywords: dyslipidemia, HIV, HAART, adipokines
Additional Information: osteodiva@gmail.com
Date Deposited: 11 Aug 2015 22:30
Last Modified: 31 Jul 2020 19:06
URI: http://d-scholarship.pitt.edu/id/eprint/20050

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