Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Synthesis of Simplified Discodermolide Analogs

Brody, Daniel M. (2014) Synthesis of Simplified Discodermolide Analogs. Master's Thesis, University of Pittsburgh. (Unpublished)

Primary Text

Download (3MB) | Preview


Discodermolide was discovered in 1990 and with its discovery set off an expansive
medicinal chemistry program fueled by many groups’ research. It acts as a microtubule
stabilizer, which makes it a potential anti-cancer agent. The synthesis of simplified
discodermolide analogs is reported here. These analogs use simplified versions of the lactone
and carbamate fragments, which are then coupled via olefin metathesis. Hologram quantitative
structure-activity relationship (HQSAR) is also used to show that an olefin linker inserted by
olefin metathesis as viable simple alternatives to the complex middle portion usually found in the
parent molecule.


Social Networking:
Share |


Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Brody, Daniel M.
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairCurran, Dennis Pcurran@pitt.eduCURRAN
Committee MemberKoide, KazunoriKoide@pitt.eduKOIDE
Committee MemberBrummond, Kay Mkbrummon@pitt.eduKBRUMMON
Committee MemberGold, Barrygoldbi@pitt.eduGOLDBI
Date: 27 January 2014
Date Type: Publication
Defense Date: 19 November 2013
Approval Date: 27 January 2014
Submission Date: 6 December 2013
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 170
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Discodermolide, Microtubules, Microtubule stabilizers
Date Deposited: 27 Jan 2014 16:48
Last Modified: 15 Nov 2016 14:16


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item