Wiley, DJ and Li, X and Hsu, H and Seaberg, EC and Cranston, RD and Young, S and D'Souza, G and Martínez-Maza, O and DeAzambuja, K and Chua, K and Hussain, SK and Detels, R
(2013)
Factors affecting the prevalence of strongly and weakly carcinogenic and lower-risk human papillomaviruses in anal specimens in a cohort of men who have sex with men (MSM).
PLoS ONE, 8 (11).
Abstract
Background: MSM are at higher risk for invasive anal cancer. Twelve human papillomaviruses (HPVs) cause cervical cancer in women (Group 1 high-risk HPVs (hrHPVs)) and 13 HPVs are probable/possible causes (Group 2 hrHPVs) of cervical malignancy. HPVs rarely associated with malignancy are classified as lower-risk HPVs (lrHPVs). Materials and Methods: Dacron-swab anal-cytology specimens were collected from and data complete for 97% (1262/1296) of Multicenter AIDS Cohort Study (MACS) men tested for HPVs using the Linear Array assay. Multivariate Poisson regression analyses estimated adjusted prevalence ratios for Group 1/2 hrHPVs and lrHPVs, controlling for the effects of age, race, ethnicity, sexual partnerships, smoking; HIV-infection characteristics, treatment, and immune status among HIV-infected men. Results: HIV-infected men showed 35-90% higher prevalence of Group 1/2 hrHPVs and lrHPVs than HIV-uninfected men, and higher prevalence of multi-Type, and multiple risk-group infections. CD4+ T-cell count was inversely associated with HPV Group 2 prevalence (p<0.0001). The number of receptive anal intercourse (RAI) partners reported in the 24 months preceding HPV testing predicted higher prevalence of Group 1/2 hrHPVs. Men reporting ≥30 lifetime male sex partners before their first MACS visit and men reporting ≥1 RAI partners during the 24 months before HPV testing showed 17-24% and 13-17% higher prevalence of lrHPVs (p-values ≤0.05). Men reporting smoking between MACS visit 1 and 24 months before HPV testing showed 1.2-fold higher prevalence of Group 2 hrHPVs (p = 0.03). Both complete adherence to CART (p = 0.02) and HIV load <50 copies/mL (p = 0.04) were protective for Group 1 hrHPVs among HIV-infected men. Conclusions: HIV-infected men more often show multi-type and multi-group HPV infections HIV-uninfected men. Long-term mutual monogamy and smoking cessation, generally, and CART-adherence that promotes (HIV) viremia control and prevents immunosuppression, specifically among HIV-infected MSM, are important prevention strategies for HPV infections that are relevant to anal cancer. © 2013 Wiley et al.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Wiley, DJ | | | | | Li, X | | | | | Hsu, H | | | | | Seaberg, EC | | | | | Cranston, RD | rdc27@pitt.edu | RDC27 | | | Young, S | | | | | D'Souza, G | | | | | Martínez-Maza, O | | | | | DeAzambuja, K | | | | | Chua, K | | | | | Hussain, SK | | | | | Detels, R | | | |
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| Contributors: |
| Contribution | Contributors Name | Email | Pitt Username | ORCID |
|---|
| Editor | Gray, Clive M | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED |
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| Date: |
20 November 2013 |
| Date Type: |
Publication |
| Journal or Publication Title: |
PLoS ONE |
| Volume: |
8 |
| Number: |
11 |
| DOI or Unique Handle: |
10.1371/journal.pone.0079492 |
| Schools and Programs: |
School of Medicine > Infectious Diseases and Microbiology |
| Refereed: |
Yes |
| Date Deposited: |
30 Jan 2014 18:03 |
| Last Modified: |
02 Feb 2019 13:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/20401 |
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