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Convergent approach to (E)-alkene and cyclopropane peptide isosteres

Wipf, P and Xiao, J (2005) Convergent approach to (E)-alkene and cyclopropane peptide isosteres. Organic Letters, 7 (1). 103 - 106. ISSN 1523-7060

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(Chemical Equation Presented) Trisubstituted (E)-alkene isosteres (TEADIs) and novel cyclopropane amide bond isosteres (CPDIs) were synthesized by aldimine addition and three-component aldimine addition-cyclopropanation methodologies, respectively. These new peptide mimetics can serve as β-turn promoters.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Wipf, Ppwipf@pitt.eduPWIPF
Xiao, J
Date: 6 January 2005
Date Type: Publication
Journal or Publication Title: Organic Letters
Volume: 7
Number: 1
Page Range: 103 - 106
DOI or Unique Handle: 10.1021/ol0477529
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 1523-7060
MeSH Headings: Alkenes--chemistry; Cyclopropanes--chemistry; Models, Molecular; Molecular Structure; Peptides--chemistry; X-Ray Diffraction
PubMed ID: 15624988
Date Deposited: 30 Jan 2014 18:12
Last Modified: 02 Feb 2019 15:57


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