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Small Molecule Regulation of Phosphatase-Dependent Cell Signaling Pathways

Lazo, JS and Wipf, P (2002) Small Molecule Regulation of Phosphatase-Dependent Cell Signaling Pathways. Oncology Research, 13 (6-10). 347 - 352. ISSN 0965-0407

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Small molecules provide exceptionally useful tools for probing signaling targets relevant for cancer and stem cell differentiation. In contrast to genetic approaches, the application of small molecules generally offers a graded and reversible disruption of a particular pathway. The vast array of theoretical chemical entities that exist in the chemical universe are now becoming available through the production and distribution of chemical libraries generated by both traditional and combinatorial methods, which are suitable for pharmacological use. Convenient and inexpensive cell-free and cell-based assays can be used to identify chemicals that exhibit desirable antisignaling properties. We illustrate a model of how agents targeted against signaling macromolecules involved in cancer, namely dual specificity protein phosphatases, can be identified.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Lazo, JS
Wipf, Ppwipf@pitt.eduPWIPF
Date: 1 January 2002
Date Type: Publication
Journal or Publication Title: Oncology Research
Volume: 13
Number: 6-10
Page Range: 347 - 352
DOI or Unique Handle: 10.3727/096504003108748555
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 0965-0407
MeSH Headings: Antineoplastic Agents--pharmacology; Cell Cycle--drug effects; Cell Transformation, Neoplastic--metabolism; Enzyme Inhibitors--pharmacology; Humans; Models, Biological; Models, Molecular; Signal Transduction--physiology; cdc25 Phosphatases--classification; cdc25 Phosphatases--drug effects
PubMed ID: 12725524
Date Deposited: 30 Jan 2014 18:25
Last Modified: 04 Jul 2020 14:55


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