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Discodermolide/Dictyostatin Hybrids: Synthesis and Biological Evaluation

Shin, Y and Choy, N and Balachandran, R and Madiraju, C and Day, BW and Curran, DP (2002) Discodermolide/Dictyostatin Hybrids: Synthesis and Biological Evaluation. Organic Letters, 4 (25). 4443 - 4446. ISSN 1523-7060

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(Matrix Presented) Two hybrid analogues of discodermolide and dictyostatin (3, 26) have been designed and synthesized. These are the first macrocyclic analogues of discodermolide and biological activities were evaluated and compared with linear discodermolide analogues.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Shin, Y
Choy, N
Balachandran, R
Madiraju, C
Day, BW
Curran, DPcurran@pitt.eduCURRAN
Date: 12 December 2002
Date Type: Publication
Journal or Publication Title: Organic Letters
Volume: 4
Number: 25
Page Range: 4443 - 4446
DOI or Unique Handle: 10.1021/ol026942l
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 1523-7060
MeSH Headings: Alkanes; Antineoplastic Agents--chemical synthesis; Antineoplastic Agents--chemistry; Antineoplastic Agents--pharmacology; Breast Neoplasms--drug therapy; Breast Neoplasms--pathology; Carbamates; Female; Humans; Lactones--chemical synthesis; Lactones--chemistry; Lactones--pharmacology; Macrolides; Ovarian Neoplasms--drug therapy; Ovarian Neoplasms--pathology; Pyrones; Tumor Cells, Cultured
PubMed ID: 12465908
Date Deposited: 07 Feb 2014 00:02
Last Modified: 30 Mar 2019 14:55


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