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Resolution of 1-(2-naphthyl)ethanol by a combination of an enzyme-catalyzed kinetic resolution with a fluorous triphasic separative reaction

Luo, Z and Swaleh, SM and Theil, F and Curran, DP (2002) Resolution of 1-(2-naphthyl)ethanol by a combination of an enzyme-catalyzed kinetic resolution with a fluorous triphasic separative reaction. Organic Letters, 4 (15). 2585 - 2587. ISSN 1523-7060

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Abstract

(Matrix presented) Kinetic resolution of a fluorous ester rac-1 with Candida antarctica B lipase provided a mixture of enantioenriched alcohol (R)-2 and fluorous ester (S)-1. The mixture was subjected to a fluorous triphasic reaction to give both enantiomers of 1-(2-naphthyl)ethanol 2 in high ee without chromatographic separation or fluorous-organic liquid-liquid extractive purification.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Luo, Z
Swaleh, SM
Theil, F
Curran, DPcurran@pitt.eduCURRAN
Date: 25 July 2002
Date Type: Publication
Journal or Publication Title: Organic Letters
Volume: 4
Number: 15
Page Range: 2585 - 2587
DOI or Unique Handle: 10.1021/ol026232f
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 1523-7060
MeSH Headings: Catalysis; Esters--chemistry; Ethanol--analogs & derivatives; Ethanol--isolation & purification; Fluorescent Dyes; Fungal Proteins; Kinetics; Lipase--metabolism; Naphthalenes--isolation & purification; Solvents--chemistry; Stereoisomerism
PubMed ID: 12123382
Date Deposited: 12 Feb 2014 23:43
Last Modified: 02 Feb 2019 15:58
URI: http://d-scholarship.pitt.edu/id/eprint/20490

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